Skip to main content
Journal cover image

Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions.

Publication ,  Journal Article
De Placido, G; Alviggi, C; Di Palma, G; Carravetta, C; Matarese, G; Landino, G; Racioppi, L
Published in: Hum Reprod
November 1998

Serum concentrations of soluble human leukocyte class I antigens (sHLA-I) and of the intercellular adhesion molecule-1 (sICAM-1) are increased in the early inflammatory stages of several immune-related diseases. These soluble molecules also exert immunomodulatory activity, including regulation of natural killer (NK) cell cytotoxicity. The aim of this study was to verify whether sHLA-I and sICAM-1 serum concentrations are related to the various stages of pelvic endometriosis, which is an immune-related disorder associated with impaired in-vitro NK cell activity. Serum sHLA-I and sICAM-1 concentrations were similar in patients and in healthy donors. However, when evaluated according to disease stage, sHLA-I and sICAM-1 concentrations were higher in patients with endometriosis stage I-II (revised American Fertility Society classification), or with non-pigmented peritoneal lesions. In conclusion, studies on sHLA-I and sICAM-1 may help to clarify the pathogenic mechanisms of endometriosis, and their serum concentrations may serve as additional markers for the early detection of recurrence of the disease during the monitoring of treatment outcome.

Duke Scholars

Published In

Hum Reprod

DOI

ISSN

0268-1161

Publication Date

November 1998

Volume

13

Issue

11

Start / End Page

3206 / 3210

Location

England

Related Subject Headings

  • Pigmentation
  • Peritoneum
  • Obstetrics & Reproductive Medicine
  • Killer Cells, Natural
  • Intercellular Adhesion Molecule-1
  • Humans
  • Histocompatibility Antigens Class I
  • Female
  • Endometriosis
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
De Placido, G., Alviggi, C., Di Palma, G., Carravetta, C., Matarese, G., Landino, G., & Racioppi, L. (1998). Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions. Hum Reprod, 13(11), 3206–3210. https://doi.org/10.1093/humrep/13.11.3206
De Placido, G., C. Alviggi, G. Di Palma, C. Carravetta, G. Matarese, G. Landino, and L. Racioppi. “Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions.Hum Reprod 13, no. 11 (November 1998): 3206–10. https://doi.org/10.1093/humrep/13.11.3206.
Journal cover image

Published In

Hum Reprod

DOI

ISSN

0268-1161

Publication Date

November 1998

Volume

13

Issue

11

Start / End Page

3206 / 3210

Location

England

Related Subject Headings

  • Pigmentation
  • Peritoneum
  • Obstetrics & Reproductive Medicine
  • Killer Cells, Natural
  • Intercellular Adhesion Molecule-1
  • Humans
  • Histocompatibility Antigens Class I
  • Female
  • Endometriosis
  • Adult