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Human brain glycogen metabolism during and after hypoglycemia.

Publication ,  Journal Article
Oz, G; Kumar, A; Rao, JP; Kodl, CT; Chow, L; Eberly, LE; Seaquist, ER
Published in: Diabetes
September 2009

OBJECTIVE: We tested the hypotheses that human brain glycogen is mobilized during hypoglycemia and its content increases above normal levels ("supercompensates") after hypoglycemia. RESEARCH DESIGN AND METHODS: We utilized in vivo (13)C nuclear magnetic resonance spectroscopy in conjunction with intravenous infusions of [(13)C]glucose in healthy volunteers to measure brain glycogen metabolism during and after euglycemic and hypoglycemic clamps. RESULTS: After an overnight intravenous infusion of 99% enriched [1-(13)C]glucose to prelabel glycogen, the rate of label wash-out from [1-(13)C]glycogen was higher (0.12 +/- 0.05 vs. 0.03 +/- 0.06 micromol x g(-1) x h(-1), means +/- SD, P < 0.02, n = 5) during a 2-h hyperinsulinemic-hypoglycemic clamp (glucose concentration 57.2 +/- 9.7 mg/dl) than during a hyperinsulinemic-euglycemic clamp (95.3 +/- 3.3 mg/dl), indicating mobilization of glucose units from glycogen during moderate hypoglycemia. Five additional healthy volunteers received intravenous 25-50% enriched [1-(13)C]glucose over 22-54 h after undergoing hyperinsulinemic-euglycemic (glucose concentration 92.4 +/- 2.3 mg/dl) and hyperinsulinemic-hypoglycemic (52.9 +/- 4.8 mg/dl) clamps separated by at least 1 month. Levels of newly synthesized glycogen measured from 4 to 80 h were higher after hypoglycemia than after euglycemia (P

Duke Scholars

Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

September 2009

Volume

58

Issue

9

Start / End Page

1978 / 1985

Location

United States

Related Subject Headings

  • Young Adult
  • Models, Biological
  • Male
  • Magnetic Resonance Spectroscopy
  • Infusions, Intravenous
  • Hypoglycemia
  • Hyperinsulinism
  • Humans
  • Glycogen
  • Glucose Clamp Technique
 

Citation

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Oz, G., Kumar, A., Rao, J. P., Kodl, C. T., Chow, L., Eberly, L. E., & Seaquist, E. R. (2009). Human brain glycogen metabolism during and after hypoglycemia. Diabetes, 58(9), 1978–1985. https://doi.org/10.2337/db09-0226
Oz, Gülin, Anjali Kumar, Jyothi P. Rao, Christopher T. Kodl, Lisa Chow, Lynn E. Eberly, and Elizabeth R. Seaquist. “Human brain glycogen metabolism during and after hypoglycemia.Diabetes 58, no. 9 (September 2009): 1978–85. https://doi.org/10.2337/db09-0226.
Oz G, Kumar A, Rao JP, Kodl CT, Chow L, Eberly LE, et al. Human brain glycogen metabolism during and after hypoglycemia. Diabetes. 2009 Sep;58(9):1978–85.
Oz, Gülin, et al. “Human brain glycogen metabolism during and after hypoglycemia.Diabetes, vol. 58, no. 9, Sept. 2009, pp. 1978–85. Pubmed, doi:10.2337/db09-0226.
Oz G, Kumar A, Rao JP, Kodl CT, Chow L, Eberly LE, Seaquist ER. Human brain glycogen metabolism during and after hypoglycemia. Diabetes. 2009 Sep;58(9):1978–1985.

Published In

Diabetes

DOI

EISSN

1939-327X

Publication Date

September 2009

Volume

58

Issue

9

Start / End Page

1978 / 1985

Location

United States

Related Subject Headings

  • Young Adult
  • Models, Biological
  • Male
  • Magnetic Resonance Spectroscopy
  • Infusions, Intravenous
  • Hypoglycemia
  • Hyperinsulinism
  • Humans
  • Glycogen
  • Glucose Clamp Technique