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Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption.

Publication ,  Journal Article
Kampov-Polevoy, AB; Overstreet, DH; Rezvani, AH; Janowsky, DS
Published in: Pharmacol Biochem Behav
September 1995

In a situation offering a free choice between 0.1% saccharin solution and tap water, Fawn Hooded (FH) rats consumed 363.0 +/- 33.5 ml/kg/day of saccharin solution. Subsequently those animals drank 3.0 +/- 0.4 g/kg of ethanol in a free choice between water and 10% ethanol solution. Control FH rats that did not have access to saccharin consumed 5.0 +/- 0.5 between groups was significant: p = 0.006). When control rats were exposed to the choice between 10% ethanol solution and 0.1% saccharin solution for 4 days they consumed 383.7 +/- 27.5 ml/kg/day of saccharin solution and their ethanol intake dropped to 1.2 +/- 0.3 g/kg/day. When these rats were returned back to alcohol/water choice and exposure to saccharin was discontinued, their alcohol intake was still reduced (3.7 +/- 0.3 g/kg/day for at least 10 consecutive days). Exposure of alcohol-experienced alcohol-preferring P rats with high (6.8 +/- 0.5 g/kg/day) and stable alcohol intake to saccharin/water choice for 4 days also resulted in a significant attenuation of their ethanol intake for at least 6 days following saccharin cessation. Thus, voluntary consumption of saccharin can suppress subsequent alcohol intake in both alcohol-naive and alcohol-experienced rats.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

September 1995

Volume

52

Issue

1

Start / End Page

59 / 64

Location

United States

Related Subject Headings

  • Saccharin
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Eating
  • Drinking
  • Depression, Chemical
  • Animals
  • Alcohol Drinking
  • Alcohol Deterrents
 

Citation

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Kampov-Polevoy, A. B., Overstreet, D. H., Rezvani, A. H., & Janowsky, D. S. (1995). Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption. Pharmacol Biochem Behav, 52(1), 59–64. https://doi.org/10.1016/0091-3057(94)00430-q
Kampov-Polevoy, A. B., D. H. Overstreet, A. H. Rezvani, and D. S. Janowsky. “Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption.Pharmacol Biochem Behav 52, no. 1 (September 1995): 59–64. https://doi.org/10.1016/0091-3057(94)00430-q.
Kampov-Polevoy AB, Overstreet DH, Rezvani AH, Janowsky DS. Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption. Pharmacol Biochem Behav. 1995 Sep;52(1):59–64.
Kampov-Polevoy, A. B., et al. “Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption.Pharmacol Biochem Behav, vol. 52, no. 1, Sept. 1995, pp. 59–64. Pubmed, doi:10.1016/0091-3057(94)00430-q.
Kampov-Polevoy AB, Overstreet DH, Rezvani AH, Janowsky DS. Suppression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption. Pharmacol Biochem Behav. 1995 Sep;52(1):59–64.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

September 1995

Volume

52

Issue

1

Start / End Page

59 / 64

Location

United States

Related Subject Headings

  • Saccharin
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Eating
  • Drinking
  • Depression, Chemical
  • Animals
  • Alcohol Drinking
  • Alcohol Deterrents