MK-801 potently inhibits alcohol withdrawal seizures in rats.
Publication
, Journal Article
Morrisett, RA; Rezvani, AH; Overstreet, D; Janowsky, DS; Wilson, WA; Swartzwelder, HS
Published in: Eur J Pharmacol
January 25, 1990
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.
Duke Scholars
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
January 25, 1990
Volume
176
Issue
1
Start / End Page
103 / 105
Location
Netherlands
Related Subject Headings
- Substance Withdrawal Syndrome
- Seizures
- Receptors, Neurotransmitter
- Receptors, N-Methyl-D-Aspartate
- Rats, Inbred Strains
- Rats
- Pharmacology & Pharmacy
- Male
- Ethanol
- Dizocilpine Maleate
Citation
APA
Chicago
ICMJE
MLA
NLM
Morrisett, R. A., Rezvani, A. H., Overstreet, D., Janowsky, D. S., Wilson, W. A., & Swartzwelder, H. S. (1990). MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol, 176(1), 103–105. https://doi.org/10.1016/0014-2999(90)90138-v
Morrisett, R. A., A. H. Rezvani, D. Overstreet, D. S. Janowsky, W. A. Wilson, and H. S. Swartzwelder. “MK-801 potently inhibits alcohol withdrawal seizures in rats.” Eur J Pharmacol 176, no. 1 (January 25, 1990): 103–5. https://doi.org/10.1016/0014-2999(90)90138-v.
Morrisett RA, Rezvani AH, Overstreet D, Janowsky DS, Wilson WA, Swartzwelder HS. MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol. 1990 Jan 25;176(1):103–5.
Morrisett, R. A., et al. “MK-801 potently inhibits alcohol withdrawal seizures in rats.” Eur J Pharmacol, vol. 176, no. 1, Jan. 1990, pp. 103–05. Pubmed, doi:10.1016/0014-2999(90)90138-v.
Morrisett RA, Rezvani AH, Overstreet D, Janowsky DS, Wilson WA, Swartzwelder HS. MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol. 1990 Jan 25;176(1):103–105.
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
January 25, 1990
Volume
176
Issue
1
Start / End Page
103 / 105
Location
Netherlands
Related Subject Headings
- Substance Withdrawal Syndrome
- Seizures
- Receptors, Neurotransmitter
- Receptors, N-Methyl-D-Aspartate
- Rats, Inbred Strains
- Rats
- Pharmacology & Pharmacy
- Male
- Ethanol
- Dizocilpine Maleate