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Vulvar manifestations of Crohn's disease.

Publication ,  Journal Article
Foo, W-C; Papalas, JA; Robboy, SJ; Selim, MA
Published in: Am J Dermatopathol
August 2011

Crohn's disease is an inflammatory bowel disorder with several well-known extraintestinal manifestations, such as erythema nodosum, uveitis, and arthritis. Less commonly observed are vulvar manifestations, which have primarily been discussed in case reports or small case series. These cases generally highlight patients with histopathology limited to noncaseating granulomas. As these histological findings are identified in bowel biopsies from only approximately 50% of patients with gastrointestinal Crohn's disease, there is likely an under-recognition and underdiagnosis of vulvar lesions as Crohn's disease manifestations. We describe the largest case series to date involving patients with vulvar Crohn's disease, discuss the varied clinical presentations, and describe the histopathological findings, which include noncaseating granulomas, ulcerations, lymphatic lesions, and even dysplasia and carcinoma. Our findings underscore the importance of keeping vulvar Crohn's disease on the differential diagnosis when faced with a range of vulvar symptoms and suggest that regular gynecological surveillance in patients with Crohn's disease may be of benefit.

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Published In

Am J Dermatopathol

DOI

EISSN

1533-0311

Publication Date

August 2011

Volume

33

Issue

6

Start / End Page

588 / 593

Location

United States

Related Subject Headings

  • Young Adult
  • Vulvar Diseases
  • Vulva
  • Middle Aged
  • Humans
  • Female
  • Dermatology & Venereal Diseases
  • Crohn Disease
  • Child
  • Adult
 

Citation

APA
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ICMJE
MLA
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Foo, W.-C., Papalas, J. A., Robboy, S. J., & Selim, M. A. (2011). Vulvar manifestations of Crohn's disease. Am J Dermatopathol, 33(6), 588–593. https://doi.org/10.1097/DAD.0b013e31820a2635
Foo, Wen-Chi, John A. Papalas, Stanley J. Robboy, and Maria A. Selim. “Vulvar manifestations of Crohn's disease.Am J Dermatopathol 33, no. 6 (August 2011): 588–93. https://doi.org/10.1097/DAD.0b013e31820a2635.
Foo W-C, Papalas JA, Robboy SJ, Selim MA. Vulvar manifestations of Crohn's disease. Am J Dermatopathol. 2011 Aug;33(6):588–93.
Foo, Wen-Chi, et al. “Vulvar manifestations of Crohn's disease.Am J Dermatopathol, vol. 33, no. 6, Aug. 2011, pp. 588–93. Pubmed, doi:10.1097/DAD.0b013e31820a2635.
Foo W-C, Papalas JA, Robboy SJ, Selim MA. Vulvar manifestations of Crohn's disease. Am J Dermatopathol. 2011 Aug;33(6):588–593.

Published In

Am J Dermatopathol

DOI

EISSN

1533-0311

Publication Date

August 2011

Volume

33

Issue

6

Start / End Page

588 / 593

Location

United States

Related Subject Headings

  • Young Adult
  • Vulvar Diseases
  • Vulva
  • Middle Aged
  • Humans
  • Female
  • Dermatology & Venereal Diseases
  • Crohn Disease
  • Child
  • Adult