Comparison of spontaneous and adaptive mutation spectra in yeast
Publication
, Journal Article
Greene, CN; Jinks-Robertson, S
Published in: Journal of Genetics
January 1, 1999
Adaptive mutations occur in nongrowing populations of cells to overcome strong, nonlethal selection conditions. Several models have been proposed for the molecular mechanism(s) for this phenomenon in Escherichia coli, but the mechanisms involved in adaptive mutagenesis in the yeast Saccharomyces cerevisiae are largely unknown. We present here a comparison of the mutational spectra of spontaneous and adaptive frameshift reversion events in yeast. In contrast to results from E. coli, we find that the mutational spectrum of adaptive mutations in S. cerevisiae is not similar to that seen in mismatch repair defective cells, but rather resembles the spontaneous mutational events that occur during normal growth.
Duke Scholars
Published In
Journal of Genetics
DOI
ISSN
0022-1333
Publication Date
January 1, 1999
Volume
78
Issue
1
Start / End Page
51 / 55
Related Subject Headings
- Evolutionary Biology
- 0604 Genetics
Citation
APA
Chicago
ICMJE
MLA
NLM
Greene, C. N., & Jinks-Robertson, S. (1999). Comparison of spontaneous and adaptive mutation spectra in yeast. Journal of Genetics, 78(1), 51–55. https://doi.org/10.1007/BF02994703
Greene, C. N., and S. Jinks-Robertson. “Comparison of spontaneous and adaptive mutation spectra in yeast.” Journal of Genetics 78, no. 1 (January 1, 1999): 51–55. https://doi.org/10.1007/BF02994703.
Greene CN, Jinks-Robertson S. Comparison of spontaneous and adaptive mutation spectra in yeast. Journal of Genetics. 1999 Jan 1;78(1):51–5.
Greene, C. N., and S. Jinks-Robertson. “Comparison of spontaneous and adaptive mutation spectra in yeast.” Journal of Genetics, vol. 78, no. 1, Jan. 1999, pp. 51–55. Scopus, doi:10.1007/BF02994703.
Greene CN, Jinks-Robertson S. Comparison of spontaneous and adaptive mutation spectra in yeast. Journal of Genetics. 1999 Jan 1;78(1):51–55.
Published In
Journal of Genetics
DOI
ISSN
0022-1333
Publication Date
January 1, 1999
Volume
78
Issue
1
Start / End Page
51 / 55
Related Subject Headings
- Evolutionary Biology
- 0604 Genetics