Cardiac GPCRs: GPCR signaling in healthy and failing hearts.
Publication
, Journal Article
Salazar, NC; Chen, J; Rockman, HA
Published in: Biochim Biophys Acta
April 2007
G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.
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Published In
Biochim Biophys Acta
DOI
ISSN
0006-3002
Publication Date
April 2007
Volume
1768
Issue
4
Start / End Page
1006 / 1018
Location
Netherlands
Related Subject Headings
- Signal Transduction
- Receptors, G-Protein-Coupled
- Phosphatidylinositol 3-Kinases
- Myocardium
- Mice
- Humans
- Heart Diseases
- Animals
- 51 Physical sciences
- 31 Biological sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Salazar, N. C., Chen, J., & Rockman, H. A. (2007). Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta, 1768(4), 1006–1018. https://doi.org/10.1016/j.bbamem.2007.02.010
Salazar, Natasha C., Juhsien Chen, and Howard A. Rockman. “Cardiac GPCRs: GPCR signaling in healthy and failing hearts.” Biochim Biophys Acta 1768, no. 4 (April 2007): 1006–18. https://doi.org/10.1016/j.bbamem.2007.02.010.
Salazar NC, Chen J, Rockman HA. Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta. 2007 Apr;1768(4):1006–18.
Salazar, Natasha C., et al. “Cardiac GPCRs: GPCR signaling in healthy and failing hearts.” Biochim Biophys Acta, vol. 1768, no. 4, Apr. 2007, pp. 1006–18. Pubmed, doi:10.1016/j.bbamem.2007.02.010.
Salazar NC, Chen J, Rockman HA. Cardiac GPCRs: GPCR signaling in healthy and failing hearts. Biochim Biophys Acta. 2007 Apr;1768(4):1006–1018.
Published In
Biochim Biophys Acta
DOI
ISSN
0006-3002
Publication Date
April 2007
Volume
1768
Issue
4
Start / End Page
1006 / 1018
Location
Netherlands
Related Subject Headings
- Signal Transduction
- Receptors, G-Protein-Coupled
- Phosphatidylinositol 3-Kinases
- Myocardium
- Mice
- Humans
- Heart Diseases
- Animals
- 51 Physical sciences
- 31 Biological sciences