Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
Publication
, Journal Article
Koch, WJ; Rockman, HA
Published in: Trends Cardiovasc Med
1999
The beta-adrenergic receptor signaling system plays a fundamental role in heart function. Signaling through beta ARs can be dampened by the actions of the beta AR kinase, a kinase whose expression and activity are elevated in chronic human heart failure. In this review we highlight studies that have used genetically engineered mice to understand how perturbations in myocardial beta AR signaling could adversely impact the pathogenesis of cardiac disease. Interrupting this process may provide novel therapeutic strategies in the treatment of human heart failure.
Duke Scholars
Published In
Trends Cardiovasc Med
DOI
ISSN
1050-1738
Publication Date
1999
Volume
9
Issue
3-4
Start / End Page
77 / 81
Location
United States
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Signal Transduction
- Myocardium
- Mice, Transgenic
- Mice
- Humans
- Heart Failure
- Gene Expression
- Disease Models, Animal
- DNA, Complementary
Citation
APA
Chicago
ICMJE
MLA
NLM
Koch, W. J., & Rockman, H. A. (1999). Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. Trends Cardiovasc Med, 9(3–4), 77–81. https://doi.org/10.1016/s1050-1738(99)00009-2
Koch, W. J., and H. A. Rockman. “Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.” Trends Cardiovasc Med 9, no. 3–4 (1999): 77–81. https://doi.org/10.1016/s1050-1738(99)00009-2.
Koch WJ, Rockman HA. Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. Trends Cardiovasc Med. 1999;9(3–4):77–81.
Koch, W. J., and H. A. Rockman. “Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.” Trends Cardiovasc Med, vol. 9, no. 3–4, 1999, pp. 77–81. Pubmed, doi:10.1016/s1050-1738(99)00009-2.
Koch WJ, Rockman HA. Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. Trends Cardiovasc Med. 1999;9(3–4):77–81.
Published In
Trends Cardiovasc Med
DOI
ISSN
1050-1738
Publication Date
1999
Volume
9
Issue
3-4
Start / End Page
77 / 81
Location
United States
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Signal Transduction
- Myocardium
- Mice, Transgenic
- Mice
- Humans
- Heart Failure
- Gene Expression
- Disease Models, Animal
- DNA, Complementary