Role of β-adrenoceptor desensitization in heart failure
Publication
, Journal Article
Rapacciuolo, A; Rockman, HA
Published in: Cardiovascular Drug Reviews
January 1, 1999
Heart failure is characterized by left ventricular dysfunction associated with a complex of symptoms that relate to inadequate perfusion of tissues and pulmonary congestion. When the heart is damaged by an insult, compensatory mechanisms mediated through activation of the sympathetic nervous system are involved to stabilize myocardial performance. Although these mechanisms can sustain cardiac function for a short time, chronic activation of sympathetic activity has adverse biological effects. This review will focus on the changes that occur in the β-adrenergic receptor pathway in the failing heart and will discuss novel approaches to therapy through manipulation of this pathway.
Duke Scholars
Published In
Cardiovascular Drug Reviews
DOI
ISSN
0897-5957
Publication Date
January 1, 1999
Volume
17
Issue
4
Start / End Page
384 / 394
Related Subject Headings
- Cardiovascular System & Hematology
- 3214 Pharmacology and pharmaceutical sciences
- 3201 Cardiovascular medicine and haematology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Rapacciuolo, A., & Rockman, H. A. (1999). Role of β-adrenoceptor desensitization in heart failure. Cardiovascular Drug Reviews, 17(4), 384–394. https://doi.org/10.1111/j.1527-3466.1999.tb00027.x
Rapacciuolo, A., and H. A. Rockman. “Role of β-adrenoceptor desensitization in heart failure.” Cardiovascular Drug Reviews 17, no. 4 (January 1, 1999): 384–94. https://doi.org/10.1111/j.1527-3466.1999.tb00027.x.
Rapacciuolo A, Rockman HA. Role of β-adrenoceptor desensitization in heart failure. Cardiovascular Drug Reviews. 1999 Jan 1;17(4):384–94.
Rapacciuolo, A., and H. A. Rockman. “Role of β-adrenoceptor desensitization in heart failure.” Cardiovascular Drug Reviews, vol. 17, no. 4, Jan. 1999, pp. 384–94. Scopus, doi:10.1111/j.1527-3466.1999.tb00027.x.
Rapacciuolo A, Rockman HA. Role of β-adrenoceptor desensitization in heart failure. Cardiovascular Drug Reviews. 1999 Jan 1;17(4):384–394.
Published In
Cardiovascular Drug Reviews
DOI
ISSN
0897-5957
Publication Date
January 1, 1999
Volume
17
Issue
4
Start / End Page
384 / 394
Related Subject Headings
- Cardiovascular System & Hematology
- 3214 Pharmacology and pharmaceutical sciences
- 3201 Cardiovascular medicine and haematology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1102 Cardiorespiratory Medicine and Haematology