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Regulation of myocardial contractility: Insights from transgenic mice.

Publication ,  Journal Article
Ben-Yehuda, O; Rockman, HA
Published in: Trends Cardiovasc Med
April 1996

Myocardial contraction occurs when calcium (Ca(2+)) is released from the sarcoplasmic reticulum, binding troponin C and allowing actin and myosin to cross link. Ca(2+) release and uptake is closely regulated by G protein-coupled β-adrenergic receptors through the action of the second messenger cAMP. An increase in cAMP level leads to phosphorylation of key regulatory proteins affecting intracellular Ca(2+) homeostasis. The β-adrenergic receptors themselves are regulated by a set of specific kinases, termed the G-protein-coupled receptor kinases (GRKs). The study of this complex system in vivo has recently been advanced by the development of transgenic and gene-targeted (knockout) mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac hemodynamics is an extremely powerful approach to the study of myocardial contractility and its regulation. This review focuses on several recent transgenic mouse models that have increased our understanding of the regulation of cardiac contractility.

Duke Scholars

Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

April 1996

Volume

6

Issue

3

Start / End Page

95 / 99

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Ben-Yehuda, O., & Rockman, H. A. (1996). Regulation of myocardial contractility: Insights from transgenic mice. Trends Cardiovasc Med, 6(3), 95–99. https://doi.org/10.1016/1050-1738(96)00010-2
Ben-Yehuda, O., and H. A. Rockman. “Regulation of myocardial contractility: Insights from transgenic mice.Trends Cardiovasc Med 6, no. 3 (April 1996): 95–99. https://doi.org/10.1016/1050-1738(96)00010-2.
Ben-Yehuda O, Rockman HA. Regulation of myocardial contractility: Insights from transgenic mice. Trends Cardiovasc Med. 1996 Apr;6(3):95–9.
Ben-Yehuda, O., and H. A. Rockman. “Regulation of myocardial contractility: Insights from transgenic mice.Trends Cardiovasc Med, vol. 6, no. 3, Apr. 1996, pp. 95–99. Pubmed, doi:10.1016/1050-1738(96)00010-2.
Ben-Yehuda O, Rockman HA. Regulation of myocardial contractility: Insights from transgenic mice. Trends Cardiovasc Med. 1996 Apr;6(3):95–99.
Journal cover image

Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

April 1996

Volume

6

Issue

3

Start / End Page

95 / 99

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology