Skip to main content
Journal cover image

Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation.

Publication ,  Journal Article
Rosenberg, PB; Vriesendorp, AE; Drazner, MH; Dries, DL; Kaiser, PA; Hynan, LS; Dimaio, JM; Meyer, D; Ring, WS; Yancy, CW
Published in: J Heart Lung Transplant
September 2005

BACKGROUND: Cyclosporine (CsA) is frequently initiated as induction therapy in patients undergoing orthotopic heart transplantation, but our experience has identified a significant rate of post-operative renal dysfunction. We therefore devised a renal-sparing cyclosporine-free induction regimen consisting of the early administration basiliximab, an interleukin-2 receptor monoclonal antibody, followed by the late initiation of cyclosporine on post-operative Day 4. METHODS: Between September 1998 and December 1999, we treated 25 patients at risk for post-operative renal dysfunction (high-risk basiliximab group) with the new induction regimen and another 33 patients not at risk (low-risk CsA group) for renal dysfunction with our standard cyclosporine protocol. We identified a historical control group (1996 through 1998) of 32 patients at risk for renal dysfunction (high-risk CsA group) who had received our standard cyclosporine protocol. RESULTS: The increase in serum creatinine levels after transplantation was less in the high-risk basiliximab group (-0.1 +/- 0.7) than in the high-risk CsA group (0.5 +/- 1.0, p < 0.02) and comparable to the low-risk CsA group (0.03 +/- 0.6). The basiliximab protocol did not increase rejection; the percentage of rejection episodes was high-risk basiliximab, 0; high-risk CsA, 13; and low-risk CsA, 3 (p = .13). CONCLUSION: Basiliximab induction therapy allows delayed initiation of cyclosporine after cardiac transplantation without an increase in rejection and reduces the risk of post-operative renal dysfunction.

Duke Scholars

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

September 2005

Volume

24

Issue

9

Start / End Page

1327 / 1331

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Surgery
  • Recombinant Fusion Proteins
  • Middle Aged
  • Male
  • Kidney
  • Immunosuppressive Agents
  • Humans
  • Heart Transplantation
  • Graft Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rosenberg, P. B., Vriesendorp, A. E., Drazner, M. H., Dries, D. L., Kaiser, P. A., Hynan, L. S., … Yancy, C. W. (2005). Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation. J Heart Lung Transplant, 24(9), 1327–1331. https://doi.org/10.1016/j.healun.2004.08.003
Rosenberg, Paul B., Ank E. Vriesendorp, Mark H. Drazner, Daniel L. Dries, Patricia A. Kaiser, Linda S. Hynan, J Michael Dimaio, Daniel Meyer, W Steves Ring, and Clyde W. Yancy. “Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation.J Heart Lung Transplant 24, no. 9 (September 2005): 1327–31. https://doi.org/10.1016/j.healun.2004.08.003.
Rosenberg PB, Vriesendorp AE, Drazner MH, Dries DL, Kaiser PA, Hynan LS, et al. Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation. J Heart Lung Transplant. 2005 Sep;24(9):1327–31.
Rosenberg, Paul B., et al. “Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation.J Heart Lung Transplant, vol. 24, no. 9, Sept. 2005, pp. 1327–31. Pubmed, doi:10.1016/j.healun.2004.08.003.
Rosenberg PB, Vriesendorp AE, Drazner MH, Dries DL, Kaiser PA, Hynan LS, Dimaio JM, Meyer D, Ring WS, Yancy CW. Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation. J Heart Lung Transplant. 2005 Sep;24(9):1327–1331.
Journal cover image

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

September 2005

Volume

24

Issue

9

Start / End Page

1327 / 1331

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Surgery
  • Recombinant Fusion Proteins
  • Middle Aged
  • Male
  • Kidney
  • Immunosuppressive Agents
  • Humans
  • Heart Transplantation
  • Graft Survival