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Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.

Publication ,  Journal Article
Mueller, S; Polley, M-Y; Lee, B; Kunwar, S; Pedain, C; Wembacher-Schröder, E; Mittermeyer, S; Westphal, M; Sampson, JH; Vogelbaum, MA ...
Published in: J Neurooncol
January 2011

The PRECISE study used convection enhanced delivery (CED) to infuse IL13-PE38QQR in patients with recurrent glioblastoma multiforme (GBM) and compared survival to Gliadel Wafers (GW). The objectives of this retrospective evaluation were to assess: (1) catheter positioning in relation to imaging features and (2) to examine the potential impact of catheter positioning, overall catheter placement and imaging features on long term clinical outcome in the PRECISE study. Catheter positioning and overall catheter placement were scored and used as a surrogate of adequate placement. Imaging studies obtained on day 43 and day 71 after resection were each retrospectively reviewed. Catheter positioning scores, catheter overall placement scores, local tumor control and imaging change scores were reviewed and correlated using Generalized Linear Mixed Models. Cox PH regression analysis was used to examine whether these imaging based variables predicted overall survival (OS) and progression free survival (PFS) after adjusting for age and KPS. Of 180 patients in the CED group, 20 patients did not undergo gross total resection. Of the remaining 160 patients only 53% of patients had fully conforming catheters in respect to overall placement and 51% had adequate catheter positioning scores. Better catheter positioning scores were not correlated with local tumor control (P = 0.61) or imaging change score (P = 0.86). OS and PFS were not correlated with catheter positioning score (OS: P = 0.53; PFS: P = 0.72 respectively), overall placement score (OS: P = 0.55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial.

Duke Scholars

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

January 2011

Volume

101

Issue

2

Start / End Page

267 / 277

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Recombinant Fusion Proteins
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Recurrence, Local
  • Magnetic Resonance Imaging
  • Linear Models
  • Karnofsky Performance Status
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mueller, S., Polley, M.-Y., Lee, B., Kunwar, S., Pedain, C., Wembacher-Schröder, E., … Chang, S. M. (2011). Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study. J Neurooncol, 101(2), 267–277. https://doi.org/10.1007/s11060-010-0255-0
Mueller, Sabine, Mei-Yin Polley, Benjamin Lee, Sandeep Kunwar, Christoph Pedain, Eva Wembacher-Schröder, Stephan Mittermeyer, et al. “Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.J Neurooncol 101, no. 2 (January 2011): 267–77. https://doi.org/10.1007/s11060-010-0255-0.
Mueller S, Polley M-Y, Lee B, Kunwar S, Pedain C, Wembacher-Schröder E, et al. Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study. J Neurooncol. 2011 Jan;101(2):267–77.
Mueller, Sabine, et al. “Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study.J Neurooncol, vol. 101, no. 2, Jan. 2011, pp. 267–77. Pubmed, doi:10.1007/s11060-010-0255-0.
Mueller S, Polley M-Y, Lee B, Kunwar S, Pedain C, Wembacher-Schröder E, Mittermeyer S, Westphal M, Sampson JH, Vogelbaum MA, Croteau D, Chang SM. Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study. J Neurooncol. 2011 Jan;101(2):267–277.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

January 2011

Volume

101

Issue

2

Start / End Page

267 / 277

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Recombinant Fusion Proteins
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Neoplasm Recurrence, Local
  • Magnetic Resonance Imaging
  • Linear Models
  • Karnofsky Performance Status