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Cigarette smoking and risk of meningioma: the effect of gender.

Publication ,  Journal Article
Claus, EB; Walsh, KM; Calvocoressi, L; Bondy, ML; Schildkraut, JM; Wrensch, M; Wiemels, JL
Published in: Cancer Epidemiol Biomarkers Prev
June 2012

BACKGROUND: A number of studies have reported on the association between smoking and meningioma risk, with inconsistent findings. We examined the effect of gender on the association between cigarette smoking and risk of intracranial meningioma in a large population-based, case-control study. METHODS: The data include 1,433 intracranial meningioma cases aged 29 to 79 years diagnosed among residents of the states of Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area and eight Texas counties between May 1, 2006 and April 28, 2011 as well as 1,349 controls that were frequency matched on age, sex, and geography. The data are analyzed separately and in a meta-analysis with six previously reported studies. RESULTS: Female cases who reported having ever smoked were at significantly decreased risk of intracranial meningioma (OR, 0.8; 95% CI, 0.7-0.9) in contrast to male cases who were at increased risk (OR, 1.3; 95% CI, 1.0-1.7). Similar findings were noted for current and past smokers. Smoking-induced risk for females did not vary by menopausal status. For males, increased duration of use (P = 0.04) as well as increasing number of pack-years (P = 0.02) was associated with elevated risk. A meta-analysis including 2,614 cases and 1,179,686 controls resulted in an OR for ever smoking of 0.82 (95% CI, 0.68-0.98) for women and 1.39 (95% CI, 1.08-1.79) for men. CONCLUSION: The association of cigarette smoking and meningioma case status varies significantly by gender with women at reduced risk and men at greater risk. IMPACT: Whether the observed differences are associated with a hormonal etiology will require additional investigation.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

June 2012

Volume

21

Issue

6

Start / End Page

943 / 950

Location

United States

Related Subject Headings

  • Smoking
  • Sex Factors
  • Risk Factors
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Humans
  • Female
  • Epidemiology
 

Citation

APA
Chicago
ICMJE
MLA
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Claus, E. B., Walsh, K. M., Calvocoressi, L., Bondy, M. L., Schildkraut, J. M., Wrensch, M., & Wiemels, J. L. (2012). Cigarette smoking and risk of meningioma: the effect of gender. Cancer Epidemiol Biomarkers Prev, 21(6), 943–950. https://doi.org/10.1158/1055-9965.EPI-11-1059
Claus, Elizabeth B., Kyle M. Walsh, Lisa Calvocoressi, Melissa L. Bondy, Joellen M. Schildkraut, Margaret Wrensch, and Joseph L. Wiemels. “Cigarette smoking and risk of meningioma: the effect of gender.Cancer Epidemiol Biomarkers Prev 21, no. 6 (June 2012): 943–50. https://doi.org/10.1158/1055-9965.EPI-11-1059.
Claus EB, Walsh KM, Calvocoressi L, Bondy ML, Schildkraut JM, Wrensch M, et al. Cigarette smoking and risk of meningioma: the effect of gender. Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):943–50.
Claus, Elizabeth B., et al. “Cigarette smoking and risk of meningioma: the effect of gender.Cancer Epidemiol Biomarkers Prev, vol. 21, no. 6, June 2012, pp. 943–50. Pubmed, doi:10.1158/1055-9965.EPI-11-1059.
Claus EB, Walsh KM, Calvocoressi L, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL. Cigarette smoking and risk of meningioma: the effect of gender. Cancer Epidemiol Biomarkers Prev. 2012 Jun;21(6):943–950.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

June 2012

Volume

21

Issue

6

Start / End Page

943 / 950

Location

United States

Related Subject Headings

  • Smoking
  • Sex Factors
  • Risk Factors
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Humans
  • Female
  • Epidemiology