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Intact negative feedback of four cardiac hormones in congestive heart failure.

Publication ,  Journal Article
Vesely, DL; San Miguel, GI; Hassan, I; Schocken, DD
Published in: Metabolism
May 2002

In 30 individuals with class III congestive heart failure (CHF), negative feedback of 4 cardiac peptide hormones, ie, long-acting natriuretic peptide (LANP), vessel dilator, kaliuretic peptide, and atrial natriuretic factor (ANF) from the same 126-amino acid (aa) prohormone were studied with the infusion of 100 ng/kg body weight (BW) for 60 minutes of each of the 4 cardiac hormones and a saline control (n = 6 for each). LANP decreased the circulating concentrations of vessel dilator, kaliuretic peptide, and ANF by 24%, 55%, and 30%, respectively. Vessel dilator decreased the circulating concentrations of ANF, kaliuretic peptide, and LANP 27%, 12%, and 62%, respectively. Kaliuretic peptide decreased the circulating concentrations of LANP, ANF, and vessel dilator 89%, 67%, and 70%, respectively. ANF decreased the circulating concentrations of LANP, vessel dilator, and kaliuretic peptide 88%, 59%, and 98%, respectively. Infusion of each of these 4 cardiac hormones decreased the excretion of the other 3 hormones into the urine by 11% to 92%. These results suggest that the respective cardiac hormones inhibit the release of each other rather than their breakdown, which would have increased their urinary concentrations. The feedback regulation of these hormones found previously in healthy humans is, thus, preserved in persons with CHF despite their increased endogenous circulating concentrations.

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Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

May 2002

Volume

51

Issue

5

Start / End Page

582 / 588

Location

United States

Related Subject Headings

  • Protein Precursors
  • Peptide Fragments
  • Middle Aged
  • Male
  • Kinetics
  • Humans
  • Heart Failure
  • Feedback, Physiological
  • Endocrinology & Metabolism
  • Atrial Natriuretic Factor
 

Citation

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Vesely, D. L., San Miguel, G. I., Hassan, I., & Schocken, D. D. (2002). Intact negative feedback of four cardiac hormones in congestive heart failure. Metabolism, 51(5), 582–588. https://doi.org/10.1053/meta.2002.31983
Vesely, David L., Gloria I. San Miguel, Imran Hassan, and Douglas D. Schocken. “Intact negative feedback of four cardiac hormones in congestive heart failure.Metabolism 51, no. 5 (May 2002): 582–88. https://doi.org/10.1053/meta.2002.31983.
Vesely DL, San Miguel GI, Hassan I, Schocken DD. Intact negative feedback of four cardiac hormones in congestive heart failure. Metabolism. 2002 May;51(5):582–8.
Vesely, David L., et al. “Intact negative feedback of four cardiac hormones in congestive heart failure.Metabolism, vol. 51, no. 5, May 2002, pp. 582–88. Pubmed, doi:10.1053/meta.2002.31983.
Vesely DL, San Miguel GI, Hassan I, Schocken DD. Intact negative feedback of four cardiac hormones in congestive heart failure. Metabolism. 2002 May;51(5):582–588.
Journal cover image

Published In

Metabolism

DOI

ISSN

0026-0495

Publication Date

May 2002

Volume

51

Issue

5

Start / End Page

582 / 588

Location

United States

Related Subject Headings

  • Protein Precursors
  • Peptide Fragments
  • Middle Aged
  • Male
  • Kinetics
  • Humans
  • Heart Failure
  • Feedback, Physiological
  • Endocrinology & Metabolism
  • Atrial Natriuretic Factor