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Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone.

Publication ,  Journal Article
Vesely, DL; San Miguel, GI; Hassan, I; Gower, WR; Schocken, DD
Published in: Endocrine
March 2002

This study was designed to determine whether four peptide hormones consisting of amino acids 1-30-long-acting natriuretic hormone (LANH), 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone [ANH])-of the 126 amino acid atrial natriuretic prohormone increase the circulating concentration of testosterone in healthy humans (n = 30). Vessel dilator, kaliuretic hormone, LANH, and ANH increased the circulating concentration of testosterone 3.8, 2.6, 3.9, and 3.4-fold, respectively (p < 0.01 for each), when infused at 100 ng/(kg of body wt . min) for 60 min. The increases in testosterone lasted 2.5-3 h after cessation of the respective atrial natriuretic peptides' infusions. ANH, vessel dilator, LANH, and kaliuretic hormone increased luteinizing hormone (LH) 3-to 8.4-fold (p < 0.001) during infusion, with the maximal increase in LH being 6.7- to 11.7-fold (p < 0.001) secondary to these cardiac hormones. Vessel dilator and kaliuretic hormone increased LH before increasing testosterone in a sequential fashion. These data suggest that four peptide hormones-ANH, LANH, vessel dilator, and kaliuretic hormone-increase the circulating con-centrations of LH and testosterone in humans.

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Published In

Endocrine

DOI

ISSN

1355-008X

Publication Date

March 2002

Volume

17

Issue

2

Start / End Page

145 / 150

Location

United States

Related Subject Headings

  • Testosterone
  • Protein Precursors
  • Peptide Fragments
  • Middle Aged
  • Male
  • Luteinizing Hormone
  • Humans
  • Endocrinology & Metabolism
  • Atrial Natriuretic Factor
  • Adult
 

Citation

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Vesely, D. L., San Miguel, G. I., Hassan, I., Gower, W. R., & Schocken, D. D. (2002). Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone. Endocrine, 17(2), 145–150. https://doi.org/10.1385/ENDO:17:2:145
Vesely, David L., Gloria I. San Miguel, Imran Hassan, William R. Gower, and Douglas D. Schocken. “Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone.Endocrine 17, no. 2 (March 2002): 145–50. https://doi.org/10.1385/ENDO:17:2:145.
Vesely DL, San Miguel GI, Hassan I, Gower WR, Schocken DD. Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone. Endocrine. 2002 Mar;17(2):145–50.
Vesely, David L., et al. “Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone.Endocrine, vol. 17, no. 2, Mar. 2002, pp. 145–50. Pubmed, doi:10.1385/ENDO:17:2:145.
Vesely DL, San Miguel GI, Hassan I, Gower WR, Schocken DD. Four cardiac hormones increase circulating concentrations of luteinizing hormone and testosterone. Endocrine. 2002 Mar;17(2):145–150.
Journal cover image

Published In

Endocrine

DOI

ISSN

1355-008X

Publication Date

March 2002

Volume

17

Issue

2

Start / End Page

145 / 150

Location

United States

Related Subject Headings

  • Testosterone
  • Protein Precursors
  • Peptide Fragments
  • Middle Aged
  • Male
  • Luteinizing Hormone
  • Humans
  • Endocrinology & Metabolism
  • Atrial Natriuretic Factor
  • Adult