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Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism.

Publication ,  Journal Article
Vesely, DL; Giordano, AT; Douglass, MA; McCormick, MT; Rodriguez-Paz, G; Schocken, DD
Published in: Am J Med Sci
October 1995

Atrial natriuretic factor (ANF), consisting of amino acids 99-126 of the 126 amino acid ANF prohormone, increases cyclic guanosine monophosphate (GMP) (thought to be the mediator of its physiologic effects) in plasma and urine of human subjects. Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide, consisting of amino acid 1-30, 31-67, and 79-98, respectively, of this same prohormone have natriuretic, diuretic, kaliuretic, and blood pressure lowering properties in humans. These three new peptide hormones increase cyclic GMP in vitro but were never investigated to determine whether they also cause extrusion of cyclic GMP from cells, resulting in an increase of cyclic GMP in plasma and/or urine. Infusion of each of these peptide hormones at their 100 ng/kg body weight/min concentrations for 60 minutes into healthy humans resulted in a sevenfold increase in cyclic GMP in plasma and urine secondary to ANF, but no significant increase secondary to the other atrial peptide hormones. Based on the current data, ANF has a unique effect on the metabolism of cyclic GMP, causing it to be extruded from the cell, whereas the other three atrial peptides represent the more classical metabolism of cyclic GMP via cyclic GMP phophodiesterases.

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Published In

Am J Med Sci

DOI

ISSN

0002-9629

Publication Date

October 1995

Volume

310

Issue

4

Start / End Page

143 / 149

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
  • Female
  • Cyclic GMP
  • Blood Pressure
  • Atrial Natriuretic Factor
  • Adult
  • 42 Health sciences
 

Citation

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Vesely, D. L., Giordano, A. T., Douglass, M. A., McCormick, M. T., Rodriguez-Paz, G., & Schocken, D. D. (1995). Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism. Am J Med Sci, 310(4), 143–149. https://doi.org/10.1097/00000441-199510000-00003
Vesely, D. L., A. T. Giordano, M. A. Douglass, M. T. McCormick, G. Rodriguez-Paz, and D. D. Schocken. “Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism.Am J Med Sci 310, no. 4 (October 1995): 143–49. https://doi.org/10.1097/00000441-199510000-00003.
Vesely DL, Giordano AT, Douglass MA, McCormick MT, Rodriguez-Paz G, Schocken DD. Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism. Am J Med Sci. 1995 Oct;310(4):143–9.
Vesely, D. L., et al. “Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism.Am J Med Sci, vol. 310, no. 4, Oct. 1995, pp. 143–49. Pubmed, doi:10.1097/00000441-199510000-00003.
Vesely DL, Giordano AT, Douglass MA, McCormick MT, Rodriguez-Paz G, Schocken DD. Atrial natriuretic peptides and cyclic guanosine monophosphate metabolism. Am J Med Sci. 1995 Oct;310(4):143–149.
Journal cover image

Published In

Am J Med Sci

DOI

ISSN

0002-9629

Publication Date

October 1995

Volume

310

Issue

4

Start / End Page

143 / 149

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
  • Female
  • Cyclic GMP
  • Blood Pressure
  • Atrial Natriuretic Factor
  • Adult
  • 42 Health sciences