Skip to main content
Journal cover image

Pregnancy in association with malignant melanoma

Publication ,  Journal Article
Reintgen, D; Slingluff, C; Wong, J; Seigler, HF
Published in: Clinical Consultations in Obstetrics and Gynecology
December 1, 1995

J.P. is a 35-year-old white female who presented in December 1988 with an irregular pigmented lesion on her right lower thigh and a palpable node in her right groin. Biopsy of the lesion showed an ulcerated, Clark Level 4. 2.7 mm malignant melanoma [Fig 1). At the time the patient was treated with a wide local excision of the primary site and a therapeutic right groin dissection. Pathology showed clear margins and 1/16 positive nodes. Her clinical course follows: 2/89 Immunotherapy with an experimental tumor cell vaccine. 1/91 Patient remarried, moved, and lost to follow-up. 11/92 Returned to the clinic 6 months pregnant. Ultrasound exam for pregnancy showed a 5.0- cm right iliac node. 12/92 Taken to the OR for a right iliac node dissection. Pathology showed 1/5 iliac nodes positive for metastatic melanoma. 2/93 Patient delivered a healthy baby boy. Metastatic melanoma present in the placenta (Fig 2). 3/93 The patient refuses any systemic therapy. 10/94 Presented with right axillary and left neck nodal metastases. CT scan of the abdomen and chest demonstrated retroperitoneal and mediastinal adenopathy (Stage 4 disease). 1/95 Patient being evaluated for 'gene' therapy program. Patient refuses systemic therapy. 4/95 Patient dies of metastatic melanoma. Son is alive and well at 2 years of age.

Duke Scholars

Published In

Clinical Consultations in Obstetrics and Gynecology

ISSN

1043-0660

Publication Date

December 1, 1995

Volume

7

Issue

4

Start / End Page

257 / 267
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reintgen, D., Slingluff, C., Wong, J., & Seigler, H. F. (1995). Pregnancy in association with malignant melanoma. Clinical Consultations in Obstetrics and Gynecology, 7(4), 257–267.
Reintgen, D., C. Slingluff, J. Wong, and H. F. Seigler. “Pregnancy in association with malignant melanoma.” Clinical Consultations in Obstetrics and Gynecology 7, no. 4 (December 1, 1995): 257–67.
Reintgen D, Slingluff C, Wong J, Seigler HF. Pregnancy in association with malignant melanoma. Clinical Consultations in Obstetrics and Gynecology. 1995 Dec 1;7(4):257–67.
Reintgen, D., et al. “Pregnancy in association with malignant melanoma.” Clinical Consultations in Obstetrics and Gynecology, vol. 7, no. 4, Dec. 1995, pp. 257–67.
Reintgen D, Slingluff C, Wong J, Seigler HF. Pregnancy in association with malignant melanoma. Clinical Consultations in Obstetrics and Gynecology. 1995 Dec 1;7(4):257–267.
Journal cover image

Published In

Clinical Consultations in Obstetrics and Gynecology

ISSN

1043-0660

Publication Date

December 1, 1995

Volume

7

Issue

4

Start / End Page

257 / 267