The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.
Publication
, Journal Article
Siedow, JN; Umbach, AL; Moore, AL
Published in: FEBS letters
March 1995
The cyanide-resistant, alternative oxidase of plant mitochondria catalyzes the four-electron reduction of oxygen to water, but the nature of the catalytic center associated with this oxidase has yet to be elucidated. We have identified conserved amino acids, including two copies of the iron-binding motif Glu-X-X-His, in the carboxy-terminal hydrophilic domain of the alternative oxidase that suggest the presence of a hydroxo-bridged binuclear iron center, analogous to that found in the enzyme methane monooxygenase. Using the known three-dimensional structures of other binuclear iron proteins, we have developed a structural model for the proposed catalytic site of the alternative oxidase based on these amino acid sequence similarities.
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Published In
FEBS letters
DOI
EISSN
1873-3468
ISSN
0014-5793
Publication Date
March 1995
Volume
362
Issue
1
Start / End Page
10 / 14
Related Subject Headings
- Water
- Protein Structure, Secondary
- Plants
- Plant Proteins
- Oxygen
- Oxidoreductases
- Oxidation-Reduction
- Molecular Sequence Data
- Mitochondrial Proteins
- Mitochondria
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Siedow, J. N., Umbach, A. L., & Moore, A. L. (1995). The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center. FEBS Letters, 362(1), 10–14. https://doi.org/10.1016/0014-5793(95)00196-g
Siedow, J. N., A. L. Umbach, and A. L. Moore. “The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.” FEBS Letters 362, no. 1 (March 1995): 10–14. https://doi.org/10.1016/0014-5793(95)00196-g.
Siedow JN, Umbach AL, Moore AL. The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center. FEBS letters. 1995 Mar;362(1):10–4.
Siedow, J. N., et al. “The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.” FEBS Letters, vol. 362, no. 1, Mar. 1995, pp. 10–14. Epmc, doi:10.1016/0014-5793(95)00196-g.
Siedow JN, Umbach AL, Moore AL. The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center. FEBS letters. 1995 Mar;362(1):10–14.
Published In
FEBS letters
DOI
EISSN
1873-3468
ISSN
0014-5793
Publication Date
March 1995
Volume
362
Issue
1
Start / End Page
10 / 14
Related Subject Headings
- Water
- Protein Structure, Secondary
- Plants
- Plant Proteins
- Oxygen
- Oxidoreductases
- Oxidation-Reduction
- Molecular Sequence Data
- Mitochondrial Proteins
- Mitochondria