Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.
Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary. We found that constitutively activated STAT3 levels correlated with aggressive clinical behavior of ovarian carcinoma specimens. Furthermore, inhibition of STAT3 reduced the motility of ovarian cancer cells in vitro. Surprisingly, we found that activated STAT3 localized not only to nuclei but also to focal adhesions in these cells. Activated STAT3 coimmunoprecipitated with phosphorylated paxillin and focal adhesion kinase and required paxillin and Src for its localization to focal adhesions. These results suggest that Janus-activated kinase/STAT signaling may contribute to ovarian cancer cell invasiveness.
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Related Subject Headings
- Trans-Activators
- STAT3 Transcription Factor
- Protein-Tyrosine Kinases
- Phosphorylation
- Phosphoproteins
- Paxillin
- Ovarian Neoplasms
- Oncology & Carcinogenesis
- NIH 3T3 Cells
- Mice
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Trans-Activators
- STAT3 Transcription Factor
- Protein-Tyrosine Kinases
- Phosphorylation
- Phosphoproteins
- Paxillin
- Ovarian Neoplasms
- Oncology & Carcinogenesis
- NIH 3T3 Cells
- Mice