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Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.

Publication ,  Journal Article
Silver, DL; Naora, H; Liu, J; Cheng, W; Montell, DJ
Published in: Cancer Res
May 15, 2004

Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary. We found that constitutively activated STAT3 levels correlated with aggressive clinical behavior of ovarian carcinoma specimens. Furthermore, inhibition of STAT3 reduced the motility of ovarian cancer cells in vitro. Surprisingly, we found that activated STAT3 localized not only to nuclei but also to focal adhesions in these cells. Activated STAT3 coimmunoprecipitated with phosphorylated paxillin and focal adhesion kinase and required paxillin and Src for its localization to focal adhesions. These results suggest that Janus-activated kinase/STAT signaling may contribute to ovarian cancer cell invasiveness.

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Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

May 15, 2004

Volume

64

Issue

10

Start / End Page

3550 / 3558

Location

United States

Related Subject Headings

  • Trans-Activators
  • STAT3 Transcription Factor
  • Protein-Tyrosine Kinases
  • Phosphorylation
  • Phosphoproteins
  • Paxillin
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • NIH 3T3 Cells
  • Mice
 

Citation

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MLA
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Silver, D. L., Naora, H., Liu, J., Cheng, W., & Montell, D. J. (2004). Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res, 64(10), 3550–3558. https://doi.org/10.1158/0008-5472.CAN-03-3959
Silver, Debra L., Honami Naora, Jinsong Liu, Wenjun Cheng, and Denise J. Montell. “Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.Cancer Res 64, no. 10 (May 15, 2004): 3550–58. https://doi.org/10.1158/0008-5472.CAN-03-3959.
Silver, Debra L., et al. “Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility.Cancer Res, vol. 64, no. 10, May 2004, pp. 3550–58. Pubmed, doi:10.1158/0008-5472.CAN-03-3959.

Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

May 15, 2004

Volume

64

Issue

10

Start / End Page

3550 / 3558

Location

United States

Related Subject Headings

  • Trans-Activators
  • STAT3 Transcription Factor
  • Protein-Tyrosine Kinases
  • Phosphorylation
  • Phosphoproteins
  • Paxillin
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • NIH 3T3 Cells
  • Mice