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Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.

Publication ,  Journal Article
Silver, DL; Montell, DJ
Published in: Cell
December 28, 2001

The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive cells. The ligand for this pathway, Unpaired (UPD), is expressed by two central cells within the migratory cell cluster. Mutations in upd or jak cause defects in migration and a reduction in the number of cells recruited to the cluster. Ectopic expression of either UPD or JAK is sufficient to induce extra epithelial cells to migrate. Thus, a localized signal activates the JAK/STAT pathway in neighboring epithelial cells, causing them to become invasive.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

December 28, 2001

Volume

107

Issue

7

Start / End Page

831 / 841

Location

United States

Related Subject Headings

  • Trans-Activators
  • Signal Transduction
  • STAT Transcription Factors
  • Protein-Tyrosine Kinases
  • Paracrine Communication
  • Ovary
  • Mutation
  • Humans
  • Female
  • Epithelial Cells
 

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Silver, D. L., & Montell, D. J. (2001). Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell, 107(7), 831–841. https://doi.org/10.1016/s0092-8674(01)00607-9
Silver, D. L., and D. J. Montell. “Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.Cell 107, no. 7 (December 28, 2001): 831–41. https://doi.org/10.1016/s0092-8674(01)00607-9.
Silver, D. L., and D. J. Montell. “Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.Cell, vol. 107, no. 7, Dec. 2001, pp. 831–41. Pubmed, doi:10.1016/s0092-8674(01)00607-9.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

December 28, 2001

Volume

107

Issue

7

Start / End Page

831 / 841

Location

United States

Related Subject Headings

  • Trans-Activators
  • Signal Transduction
  • STAT Transcription Factors
  • Protein-Tyrosine Kinases
  • Paracrine Communication
  • Ovary
  • Mutation
  • Humans
  • Female
  • Epithelial Cells