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Chemoattractant receptors on phagocytic cells.

Publication ,  Journal Article
Snyderman, R; Pike, MC
Published in: Annu Rev Immunol
1984

Chemoattractant receptors on leukocytes can trigger a number of cellular responses, including the cytoskeletal reorganization, changes in cell shape, directed motility, lysosomal enzyme secretion, and activation of the respiratory burst. The dose of chemoattractants required to induce motility-related functions is generally at least ten-fold smaller than the dose required to initiate secretory and respiratory burst activities. This finding and other pharmacological evidence clearly indicate that the two types of functions (i.e. motility and secretion) are regulated differently and can be divergently modified by drugs. The affinity of the oligopeptide chemoattractant receptor on polymorphonuclear leukocytes and macrophages is heterogeneous and dynamically regulated by guanine nucleotides and prior agonist exposure. High- and low-affinity forms of the oligopeptide receptor have been identified by direct binding studies. Our data suggest that low doses of agonists can initiate interconversion of low- and high-affinity states of that portion of chemoattractant receptors regulated by guanine nucleotides. On the other hand, high doses of agonists sufficient to induce chemotactic desensitization, lysosomal enzyme secretion, and the respiratory burst lead to the formation of a new population of high-affinity receptors. These binding sites are insensitive to the effects of guanine nucleotides and appear to be rapidly internalized. Transmethylation reactions mediated by S-adenosyl methionine are required for the activation of a phospholipase and release of arachidonate from leukocytes by chemotactic factors. We suggest that release of arachidonate from membrane phospholipid activates and translocates a cytosolic but loosely membrane-associated protein kinase C into the membrane and that this kinase participates in stimulus-response coupling of chemoattractant receptors.

Duke Scholars

Published In

Annu Rev Immunol

DOI

ISSN

0732-0582

Publication Date

1984

Volume

2

Start / End Page

257 / 281

Location

United States

Related Subject Headings

  • Receptors, Immunologic
  • Protein Kinase C
  • Protein Binding
  • Neutrophils
  • Methylation
  • Membrane Lipids
  • Macrophages
  • Macromolecular Substances
  • Leukotriene B4
  • Immunology
 

Citation

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MLA
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Snyderman, R., & Pike, M. C. (1984). Chemoattractant receptors on phagocytic cells. Annu Rev Immunol, 2, 257–281. https://doi.org/10.1146/annurev.iy.02.040184.001353
Snyderman, R., and M. C. Pike. “Chemoattractant receptors on phagocytic cells.Annu Rev Immunol 2 (1984): 257–81. https://doi.org/10.1146/annurev.iy.02.040184.001353.
Snyderman R, Pike MC. Chemoattractant receptors on phagocytic cells. Annu Rev Immunol. 1984;2:257–81.
Snyderman, R., and M. C. Pike. “Chemoattractant receptors on phagocytic cells.Annu Rev Immunol, vol. 2, 1984, pp. 257–81. Pubmed, doi:10.1146/annurev.iy.02.040184.001353.
Snyderman R, Pike MC. Chemoattractant receptors on phagocytic cells. Annu Rev Immunol. 1984;2:257–281.

Published In

Annu Rev Immunol

DOI

ISSN

0732-0582

Publication Date

1984

Volume

2

Start / End Page

257 / 281

Location

United States

Related Subject Headings

  • Receptors, Immunologic
  • Protein Kinase C
  • Protein Binding
  • Neutrophils
  • Methylation
  • Membrane Lipids
  • Macrophages
  • Macromolecular Substances
  • Leukotriene B4
  • Immunology