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Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.

Publication ,  Journal Article
Gewurz, H; Pickering, RJ; Christian, CL; Snyderman, R; Mergenhagen, SE; Good, RA
Published in: Clin Exp Immunol
June 1968

In both C'1q protein and agglutination assays, markedly reduced mean titres (27 and <10% normal, respectively) were observed in Swiss type lymphopenic agammaglobulinaemia. Mean C'1q titres were somewhat decreased in other forms of agammaglobulinaemia, but not to the same degree (78 and 46% normal, respectively). C'1q titres were normal or elevated in other diseases associated with repeated infections and malignancy. We conclude that the C'1q globulins, like the immunoglobulins, characteristically are deficient in agammaglobulinaemia syndromes. Since the greatest C'1q deficiencies were seen in lymphopenic agammaglobulinaemia of the Swiss type, titration of C'1q seems to be a convenient aid in diagnosing this disease early in life. Thus, the inborn error of agammaglobulinaemia seems to be reflected in the complement system.

Duke Scholars

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

June 1968

Volume

3

Issue

5

Start / End Page

437 / 445

Location

England

Related Subject Headings

  • Metabolism, Inborn Errors
  • Immunology
  • Humans
  • Hemolysis
  • Complement System Proteins
  • Chemical Precipitation
  • Agglutination Tests
  • Agglutination
  • Agammaglobulinemia
  • 3204 Immunology
 

Citation

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Gewurz, H., Pickering, R. J., Christian, C. L., Snyderman, R., Mergenhagen, S. E., & Good, R. A. (1968). Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system. Clin Exp Immunol, 3(5), 437–445.
Gewurz, H., R. J. Pickering, C. L. Christian, R. Snyderman, S. E. Mergenhagen, and R. A. Good. “Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.Clin Exp Immunol 3, no. 5 (June 1968): 437–45.
Gewurz H, Pickering RJ, Christian CL, Snyderman R, Mergenhagen SE, Good RA. Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system. Clin Exp Immunol. 1968 Jun;3(5):437–45.
Gewurz H, Pickering RJ, Christian CL, Snyderman R, Mergenhagen SE, Good RA. Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system. Clin Exp Immunol. 1968 Jun;3(5):437–445.
Journal cover image

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

June 1968

Volume

3

Issue

5

Start / End Page

437 / 445

Location

England

Related Subject Headings

  • Metabolism, Inborn Errors
  • Immunology
  • Humans
  • Hemolysis
  • Complement System Proteins
  • Chemical Precipitation
  • Agglutination Tests
  • Agglutination
  • Agammaglobulinemia
  • 3204 Immunology