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Autonomous Boolean modelling of developmental gene regulatory networks.

Publication ,  Journal Article
Cheng, X; Sun, M; Socolar, JES
Published in: Journal of the Royal Society, Interface
January 2013

During early embryonic development, a network of regulatory interactions among genes dynamically determines a pattern of differentiated tissues. We show that important timing information associated with the interactions can be faithfully represented in autonomous Boolean models in which binary variables representing expression levels are updated in continuous time, and that such models can provide a direct insight into features that are difficult to extract from ordinary differential equation (ODE) models. As an application, we model the experimentally well-studied network controlling fly body segmentation. The Boolean model successfully generates the patterns formed in normal and genetically perturbed fly embryos, permits the derivation of constraints on the time delay parameters, clarifies the logic associated with different ODE parameter sets and provides a platform for studying connectivity and robustness in parameter space. By elucidating the role of regulatory time delays in pattern formation, the results suggest new types of experimental measurements in early embryonic development.

Duke Scholars

Published In

Journal of the Royal Society, Interface

DOI

EISSN

1742-5662

ISSN

1742-5689

Publication Date

January 2013

Volume

10

Issue

78

Start / End Page

20120574

Related Subject Headings

  • Models, Genetic
  • Humans
  • General Science & Technology
  • Gene Expression Regulation, Developmental
  • Embryonic Development
  • Animals
 

Citation

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Cheng, X., Sun, M., & Socolar, J. E. S. (2013). Autonomous Boolean modelling of developmental gene regulatory networks. Journal of the Royal Society, Interface, 10(78), 20120574. https://doi.org/10.1098/rsif.2012.0574
Cheng, Xianrui, Mengyang Sun, and Joshua E. S. Socolar. “Autonomous Boolean modelling of developmental gene regulatory networks.Journal of the Royal Society, Interface 10, no. 78 (January 2013): 20120574. https://doi.org/10.1098/rsif.2012.0574.
Cheng X, Sun M, Socolar JES. Autonomous Boolean modelling of developmental gene regulatory networks. Journal of the Royal Society, Interface. 2013 Jan;10(78):20120574.
Cheng, Xianrui, et al. “Autonomous Boolean modelling of developmental gene regulatory networks.Journal of the Royal Society, Interface, vol. 10, no. 78, Jan. 2013, p. 20120574. Epmc, doi:10.1098/rsif.2012.0574.
Cheng X, Sun M, Socolar JES. Autonomous Boolean modelling of developmental gene regulatory networks. Journal of the Royal Society, Interface. 2013 Jan;10(78):20120574.
Journal cover image

Published In

Journal of the Royal Society, Interface

DOI

EISSN

1742-5662

ISSN

1742-5689

Publication Date

January 2013

Volume

10

Issue

78

Start / End Page

20120574

Related Subject Headings

  • Models, Genetic
  • Humans
  • General Science & Technology
  • Gene Expression Regulation, Developmental
  • Embryonic Development
  • Animals