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Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

Publication ,  Journal Article
Soderling, SH; Langeberg, LK; Soderling, JA; Davee, SM; Simerly, R; Raber, J; Scott, JD
Published in: Proc Natl Acad Sci U S A
February 18, 2003

The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

February 18, 2003

Volume

100

Issue

4

Start / End Page

1723 / 1728

Location

United States

Related Subject Headings

  • Wiskott-Aldrich Syndrome Protein Family
  • Polymerase Chain Reaction
  • Motor Activity
  • Microfilament Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Memory
  • Learning
  • In Situ Hybridization
 

Citation

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Soderling, S. H., Langeberg, L. K., Soderling, J. A., Davee, S. M., Simerly, R., Raber, J., & Scott, J. D. (2003). Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A, 100(4), 1723–1728. https://doi.org/10.1073/pnas.0438033100
Soderling, Scott H., Lorene K. Langeberg, Jacquelyn A. Soderling, Stephen M. Davee, Richard Simerly, Jacob Raber, and John D. Scott. “Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.Proc Natl Acad Sci U S A 100, no. 4 (February 18, 2003): 1723–28. https://doi.org/10.1073/pnas.0438033100.
Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, et al. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723–8.
Soderling, Scott H., et al. “Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.Proc Natl Acad Sci U S A, vol. 100, no. 4, Feb. 2003, pp. 1723–28. Pubmed, doi:10.1073/pnas.0438033100.
Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723–1728.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

February 18, 2003

Volume

100

Issue

4

Start / End Page

1723 / 1728

Location

United States

Related Subject Headings

  • Wiskott-Aldrich Syndrome Protein Family
  • Polymerase Chain Reaction
  • Motor Activity
  • Microfilament Proteins
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Memory
  • Learning
  • In Situ Hybridization