Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.
Publication
, Journal Article
Soderling, SH; Langeberg, LK; Soderling, JA; Davee, SM; Simerly, R; Raber, J; Scott, JD
Published in: Proc Natl Acad Sci U S A
February 18, 2003
The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
February 18, 2003
Volume
100
Issue
4
Start / End Page
1723 / 1728
Location
United States
Related Subject Headings
- Wiskott-Aldrich Syndrome Protein Family
- Polymerase Chain Reaction
- Motor Activity
- Microfilament Proteins
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Memory
- Learning
- In Situ Hybridization
Citation
APA
Chicago
ICMJE
MLA
NLM
Soderling, S. H., Langeberg, L. K., Soderling, J. A., Davee, S. M., Simerly, R., Raber, J., & Scott, J. D. (2003). Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A, 100(4), 1723–1728. https://doi.org/10.1073/pnas.0438033100
Soderling, Scott H., Lorene K. Langeberg, Jacquelyn A. Soderling, Stephen M. Davee, Richard Simerly, Jacob Raber, and John D. Scott. “Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.” Proc Natl Acad Sci U S A 100, no. 4 (February 18, 2003): 1723–28. https://doi.org/10.1073/pnas.0438033100.
Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, et al. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723–8.
Soderling, Scott H., et al. “Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.” Proc Natl Acad Sci U S A, vol. 100, no. 4, Feb. 2003, pp. 1723–28. Pubmed, doi:10.1073/pnas.0438033100.
Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723–1728.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
February 18, 2003
Volume
100
Issue
4
Start / End Page
1723 / 1728
Location
United States
Related Subject Headings
- Wiskott-Aldrich Syndrome Protein Family
- Polymerase Chain Reaction
- Motor Activity
- Microfilament Proteins
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
- Memory
- Learning
- In Situ Hybridization