The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.
Publication
, Journal Article
Soderling, SH; Binns, KL; Wayman, GA; Davee, SM; Ong, SH; Pawson, T; Scott, JD
Published in: Nat Cell Biol
December 2002
WAVE-1, which is also known as Scar, is a scaffolding protein that directs actin reorganization by relaying signals from the GTPase Rac to the Arp2/3 complex. Although the molecular details of WAVE activation by Rac have been described, the mechanisms by which these signals are terminated remain unknown. Here we have used tandem mass spectrometry to identify previously unknown components of the WAVE signalling network including WRP, a Rac-selective GTPase-activating protein. WRP binds directly to WAVE-1 through its Src homology domain 3 and specifically inhibits Rac function in vivo. Thus, we propose that WRP is a binding partner of WAVE-1 that functions as a signal termination factor for Rac.
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Published In
Nat Cell Biol
DOI
ISSN
1465-7392
Publication Date
December 2002
Volume
4
Issue
12
Start / End Page
970 / 975
Location
England
Related Subject Headings
- rac GTP-Binding Proteins
- Wiskott-Aldrich Syndrome Protein Family
- Sequence Alignment
- Rats, Sprague-Dawley
- Rats
- Protein Binding
- Molecular Sequence Data
- Microfilament Proteins
- Developmental Biology
- Binding Sites
Citation
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NLM
Soderling, S. H., Binns, K. L., Wayman, G. A., Davee, S. M., Ong, S. H., Pawson, T., & Scott, J. D. (2002). The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol, 4(12), 970–975. https://doi.org/10.1038/ncb886
Soderling, Scott H., Kathleen L. Binns, Gary A. Wayman, Stephen M. Davee, Siew Hwa Ong, Tony Pawson, and John D. Scott. “The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.” Nat Cell Biol 4, no. 12 (December 2002): 970–75. https://doi.org/10.1038/ncb886.
Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T, et al. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol. 2002 Dec;4(12):970–5.
Soderling, Scott H., et al. “The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.” Nat Cell Biol, vol. 4, no. 12, Dec. 2002, pp. 970–75. Pubmed, doi:10.1038/ncb886.
Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T, Scott JD. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol. 2002 Dec;4(12):970–975.
Published In
Nat Cell Biol
DOI
ISSN
1465-7392
Publication Date
December 2002
Volume
4
Issue
12
Start / End Page
970 / 975
Location
England
Related Subject Headings
- rac GTP-Binding Proteins
- Wiskott-Aldrich Syndrome Protein Family
- Sequence Alignment
- Rats, Sprague-Dawley
- Rats
- Protein Binding
- Molecular Sequence Data
- Microfilament Proteins
- Developmental Biology
- Binding Sites