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Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.

Publication ,  Journal Article
Zhu, H; Soher, BJ; Ouwerkerk, R; Schär, M; Barker, PB
Published in: Magn Reson Med
May 2013

Two approaches to high-resolution SENSE-encoded magnetic resonance spectroscopic imaging (MRSI) of the human brain at 7 Tesla (T) with whole-slice coverage are described. Both sequences use high-bandwidth radiofrequency pulses to reduce chemical shift displacement artifacts, SENSE-encoding to reduce scan time, and dual-band water and lipid suppression optimized for 7 T. Simultaneous B0 and transmit B1 mapping was also used for both sequences to optimize field homogeneity using high-order shimming and determine optimum radiofrequency transmit level, respectively. One sequence ("Hahn-MRSI") used reduced flip angle (90°) refocusing pulses for lower radiofrequency power deposition, while the other sequence used adiabatic fast passage refocusing pulses for improved sensitivity and reduced signal dependence on the transmit-B1 level. In four normal subjects, adiabatic fast passage-MRSI showed a signal-to-noise ratio improvement of 3.2±0.5 compared to Hahn-MRSI at the same spatial resolution, pulse repetition time, echo time, and SENSE-acceleration factor. An interleaved two-slice Hahn-MRSI sequence is also demonstrated to be experimentally feasible.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

May 2013

Volume

69

Issue

5

Start / End Page

1217 / 1225

Location

United States

Related Subject Headings

  • Spin Labels
  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy
  • Humans
  • Female
  • Echo-Planar Imaging
 

Citation

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Zhu, H., Soher, B. J., Ouwerkerk, R., Schär, M., & Barker, P. B. (2013). Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses. Magn Reson Med, 69(5), 1217–1225. https://doi.org/10.1002/mrm.24357
Zhu, He, Brian J. Soher, Ronald Ouwerkerk, Michael Schär, and Peter B. Barker. “Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.Magn Reson Med 69, no. 5 (May 2013): 1217–25. https://doi.org/10.1002/mrm.24357.
Zhu H, Soher BJ, Ouwerkerk R, Schär M, Barker PB. Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses. Magn Reson Med. 2013 May;69(5):1217–25.
Zhu, He, et al. “Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.Magn Reson Med, vol. 69, no. 5, May 2013, pp. 1217–25. Pubmed, doi:10.1002/mrm.24357.
Zhu H, Soher BJ, Ouwerkerk R, Schär M, Barker PB. Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses. Magn Reson Med. 2013 May;69(5):1217–1225.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

May 2013

Volume

69

Issue

5

Start / End Page

1217 / 1225

Location

United States

Related Subject Headings

  • Spin Labels
  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Spectroscopy
  • Humans
  • Female
  • Echo-Planar Imaging