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1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS

Publication ,  Journal Article
Suhy, J; Rooney, WD; Goodkin, DE; Capizzano, AA; Soher, BJ; Maudsley, AA; Waubant, E; Andersson, PB; Weiner, MW
Published in: Multiple Sclerosis
2000

Objective: To compare brain metabolite levels in patients with primary progressive (PP) and relapsing remitting (RR) MS and controls. Hypotheses: (1) creatine (Cr), a putative marker of gliosis, is elevated and N-acetylaspartate (NAA), a putative marker of axonal density and functional integrity, is reduced in PPMS lesions and normal appearing white matter (NAWM) compared to control white matter; (2) The pattern of metabolite change in PPMS is different than in RRMS. Methods: MRI and proton magnetic resonance spectroscopic imaging (1H MRSI) were collected from 15 PPMS patients, 13 RRMS patients, and 20 controls. Results: Cr was increased in PPMS NAWM compared to controls (P=0.035), and compared to RRMS NAWM (P=0.038). Cr was increased in focal MRI lesions from PPMS compared to lesions from RRMS (P=0.044) and compared to control white matter (P=0.041). NAA was similarly reduced in PPMS and RRMS NAWM compared to control. NAA was similarly reduced in PPMS and RRMS lesions, compared to control white matter. Conclusions: Creatine is higher in PPMS than RRMS NAWM and focal lesions. This observation is consistent with the notion that progressive disability in PPMS reflects increased gliosis and axonal loss whereas disability in RRMS reflects the cumulative effects of acute inflammatory lesions and axonal loss.

Duke Scholars

Published In

Multiple Sclerosis

Publication Date

2000

Volume

6

Issue

3

Start / End Page

148 / 155

Related Subject Headings

  • Neurology & Neurosurgery
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Suhy, J., Rooney, W. D., Goodkin, D. E., Capizzano, A. A., Soher, B. J., Maudsley, A. A., … Weiner, M. W. (2000). 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Multiple Sclerosis, 6(3), 148–155.
Suhy, J., W. D. Rooney, D. E. Goodkin, A. A. Capizzano, B. J. Soher, A. A. Maudsley, E. Waubant, P. B. Andersson, and M. W. Weiner. “1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.” Multiple Sclerosis 6, no. 3 (2000): 148–55.
Suhy J, Rooney WD, Goodkin DE, Capizzano AA, Soher BJ, Maudsley AA, et al. 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Multiple Sclerosis. 2000;6(3):148–55.
Suhy, J., et al. “1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.” Multiple Sclerosis, vol. 6, no. 3, 2000, pp. 148–55.
Suhy J, Rooney WD, Goodkin DE, Capizzano AA, Soher BJ, Maudsley AA, Waubant E, Andersson PB, Weiner MW. 1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS. Multiple Sclerosis. 2000;6(3):148–155.

Published In

Multiple Sclerosis

Publication Date

2000

Volume

6

Issue

3

Start / End Page

148 / 155

Related Subject Headings

  • Neurology & Neurosurgery
  • 1109 Neurosciences
  • 1103 Clinical Sciences