Skip to main content
Journal cover image

Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.

Publication ,  Journal Article
Gardner, JR; Hess, CP; Webb, AG; Tsika, RW; Dawson, MJ; Gulani, V
Published in: Magn Reson Med
June 2001

This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed that apparent bone volume fraction, trabecular number, and trabecular thickness were decreased, and apparent trabecular spacing increased, significantly (P < 0.05) in hindlimb-suspended mice compared to controls. These changes agreed well with light microscopy measurements from an independent study and also with actual spaceflight experiments with rats.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

June 2001

Volume

45

Issue

6

Start / End Page

1122 / 1125

Location

United States

Related Subject Headings

  • Weightlessness Simulation
  • Tibia
  • Nuclear Medicine & Medical Imaging
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Bone and Bones
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gardner, J. R., Hess, C. P., Webb, A. G., Tsika, R. W., Dawson, M. J., & Gulani, V. (2001). Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity. Magn Reson Med, 45(6), 1122–1125. https://doi.org/10.1002/mrm.1148
Gardner, J. R., C. P. Hess, A. G. Webb, R. W. Tsika, M. J. Dawson, and V. Gulani. “Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.Magn Reson Med 45, no. 6 (June 2001): 1122–25. https://doi.org/10.1002/mrm.1148.
Gardner JR, Hess CP, Webb AG, Tsika RW, Dawson MJ, Gulani V. Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity. Magn Reson Med. 2001 Jun;45(6):1122–5.
Gardner, J. R., et al. “Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.Magn Reson Med, vol. 45, no. 6, June 2001, pp. 1122–25. Pubmed, doi:10.1002/mrm.1148.
Gardner JR, Hess CP, Webb AG, Tsika RW, Dawson MJ, Gulani V. Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity. Magn Reson Med. 2001 Jun;45(6):1122–1125.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

June 2001

Volume

45

Issue

6

Start / End Page

1122 / 1125

Location

United States

Related Subject Headings

  • Weightlessness Simulation
  • Tibia
  • Nuclear Medicine & Medical Imaging
  • Microscopy
  • Mice
  • Magnetic Resonance Imaging
  • Imaging, Three-Dimensional
  • Image Processing, Computer-Assisted
  • Bone and Bones
  • Animals