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Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis

Publication ,  Journal Article
Weiner, MW; Maudsley, A; Schuff, N; Soher, BJ; Vermathen, P; Fein, G; Laxer, K
Published in: Proceedings of SPIE - The International Society for Optical Engineering
December 1, 1998

Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

December 1, 1998

Volume

3337

Start / End Page

203 / 209

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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ICMJE
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Weiner, M. W., Maudsley, A., Schuff, N., Soher, B. J., Vermathen, P., Fein, G., & Laxer, K. (1998). Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis. Proceedings of SPIE - The International Society for Optical Engineering, 3337, 203–209. https://doi.org/10.1117/12.312565
Weiner, M. W., A. Maudsley, N. Schuff, B. J. Soher, P. Vermathen, G. Fein, and K. Laxer. “Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis.” Proceedings of SPIE - The International Society for Optical Engineering 3337 (December 1, 1998): 203–9. https://doi.org/10.1117/12.312565.
Weiner MW, Maudsley A, Schuff N, Soher BJ, Vermathen P, Fein G, et al. Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis. Proceedings of SPIE - The International Society for Optical Engineering. 1998 Dec 1;3337:203–9.
Weiner, M. W., et al. “Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 3337, Dec. 1998, pp. 203–09. Scopus, doi:10.1117/12.312565.
Weiner MW, Maudsley A, Schuff N, Soher BJ, Vermathen P, Fein G, Laxer K. Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis. Proceedings of SPIE - The International Society for Optical Engineering. 1998 Dec 1;3337:203–209.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

December 1, 1998

Volume

3337

Start / End Page

203 / 209

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering