Whole-cell membrane current and membrane resistance during hypoxic spreading depression.
Publication
, Journal Article
Czéh, G; Aitken, PG; Somjen, GG
Published in: Neuroreport
February 1992
In rat hippocampal tissue slices we recorded extracellular potential (Vo) and whole-cell patch clamp current of CA1 pyramid cells. During hypoxic spreading depression (SD)-like depolarization, the holding current (Ih) increased sharply. Membrane 'slope' resistance (Rm) decreased to 10-67% (mean 39%) of the resting value. The SD-related membrane current (ISD) reversed near zero mV. With voltage dependent K+ and Na+ currents blocked by Cs+ and QX-314, shifts of Ih and decrease of Rm during SD were not suppressed. We conclude that hypoxic SD of CA1 pyramidal cells is associated with a large non-selective inward current through yet to be identified membrane mechanisms, which cannot fully explain the SD-related Vo shift.
Published In
Neuroreport
DOI
ISSN
0959-4965
Publication Date
February 1992
Volume
3
Issue
2
Start / End Page
197 / 200
Location
England
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Membrane Potentials
- In Vitro Techniques
- Hippocampus
- Female
- Cortical Spreading Depression
- Cell Hypoxia
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Czéh, G., Aitken, P. G., & Somjen, G. G. (1992). Whole-cell membrane current and membrane resistance during hypoxic spreading depression. Neuroreport, 3(2), 197–200. https://doi.org/10.1097/00001756-199202000-00019
Czéh, G., P. G. Aitken, and G. G. Somjen. “Whole-cell membrane current and membrane resistance during hypoxic spreading depression.” Neuroreport 3, no. 2 (February 1992): 197–200. https://doi.org/10.1097/00001756-199202000-00019.
Czéh G, Aitken PG, Somjen GG. Whole-cell membrane current and membrane resistance during hypoxic spreading depression. Neuroreport. 1992 Feb;3(2):197–200.
Czéh, G., et al. “Whole-cell membrane current and membrane resistance during hypoxic spreading depression.” Neuroreport, vol. 3, no. 2, Feb. 1992, pp. 197–200. Pubmed, doi:10.1097/00001756-199202000-00019.
Czéh G, Aitken PG, Somjen GG. Whole-cell membrane current and membrane resistance during hypoxic spreading depression. Neuroreport. 1992 Feb;3(2):197–200.
Published In
Neuroreport
DOI
ISSN
0959-4965
Publication Date
February 1992
Volume
3
Issue
2
Start / End Page
197 / 200
Location
England
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Neurology & Neurosurgery
- Membrane Potentials
- In Vitro Techniques
- Hippocampus
- Female
- Cortical Spreading Depression
- Cell Hypoxia
- Animals