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Nmr investigation of a microtubule binding region peptide from human tau (τ) protein

Publication ,  Journal Article
De Serrano, V; Ribeiro, AA; Strittmatter, WJ; Spicer, LD
Published in: Protein and Peptide Letters
December 1, 1997

Solution NMR studies of τD1, an 18-residue microtubule binding peptide from domain 1 of human tau protein, are reported. Using 2D 1H NMR (TOCSY, NOESY and ROESY) at 5 and 37°C, we assigned the resonances of almost all protons of τD1 at pH 4.2,5.8 and 7.3. While overall the peptide is highly disordered, several medium range NOE's give evidence for conformational preferences involving a bend at the T8-Q14 segment of the peptide.

Duke Scholars

Published In

Protein and Peptide Letters

ISSN

0929-8665

Publication Date

December 1, 1997

Volume

4

Issue

3

Start / End Page

165 / 172

Related Subject Headings

  • Biophysics
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry
 

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De Serrano, V., Ribeiro, A. A., Strittmatter, W. J., & Spicer, L. D. (1997). Nmr investigation of a microtubule binding region peptide from human tau (τ) protein. Protein and Peptide Letters, 4(3), 165–172.
De Serrano, V., A. A. Ribeiro, W. J. Strittmatter, and L. D. Spicer. “Nmr investigation of a microtubule binding region peptide from human tau (τ) protein.” Protein and Peptide Letters 4, no. 3 (December 1, 1997): 165–72.
De Serrano V, Ribeiro AA, Strittmatter WJ, Spicer LD. Nmr investigation of a microtubule binding region peptide from human tau (τ) protein. Protein and Peptide Letters. 1997 Dec 1;4(3):165–72.
De Serrano, V., et al. “Nmr investigation of a microtubule binding region peptide from human tau (τ) protein.” Protein and Peptide Letters, vol. 4, no. 3, Dec. 1997, pp. 165–72.
De Serrano V, Ribeiro AA, Strittmatter WJ, Spicer LD. Nmr investigation of a microtubule binding region peptide from human tau (τ) protein. Protein and Peptide Letters. 1997 Dec 1;4(3):165–172.
Journal cover image

Published In

Protein and Peptide Letters

ISSN

0929-8665

Publication Date

December 1, 1997

Volume

4

Issue

3

Start / End Page

165 / 172

Related Subject Headings

  • Biophysics
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry