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Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study.

Publication ,  Journal Article
Coffey, CE; Wilkinson, WE; Weiner, RD; Parashos, IA; Djang, WT; Webb, MC; Figiel, GS; Spritzer, CE
Published in: Arch Gen Psychiatry
January 1993

Magnetic resonance imaging was used to examine cerebral anatomy in 48 inpatients with severe depression who were referred for electroconvulsive therapy and in 76 normal control subjects. The magnetic resonance imaging measures included determinations of regional cerebral volumes and ratings of the frequency and severity of cortical atrophy, lateral ventricular enlargement, and subcortical hyperintensity. The mean total frontal lobe volume was found to be 7% smaller in the inpatients with severe depression (235.88 mL) than in the normal control subjects (254.32 mL)--a difference that was statistically significant even after adjusting for the effects of age, sex, education, and intracranial size. No group differences were observed in the volumes of the cerebral hemispheres, the temporal lobes, or the amygdala-hippocampal complex, nor in the frequency of cortical atrophy. Neither did the groups differ with respect to the total volumes of the lateral and third ventricles, nor in the frequency of lateral ventricular enlargement. Patients with depression had a significantly higher frequency of subcortical hyperintensity in the periventricular white matter, with an odds ratio of 5.32.

Duke Scholars

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

January 1993

Volume

50

Issue

1

Start / End Page

7 / 16

Location

United States

Related Subject Headings

  • Psychiatry
  • Odds Ratio
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hospitalization
  • Hippocampus
  • Functional Laterality
  • Female
 

Citation

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Coffey, C. E., Wilkinson, W. E., Weiner, R. D., Parashos, I. A., Djang, W. T., Webb, M. C., … Spritzer, C. E. (1993). Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry, 50(1), 7–16. https://doi.org/10.1001/archpsyc.1993.01820130009002
Coffey, C. E., W. E. Wilkinson, R. D. Weiner, I. A. Parashos, W. T. Djang, M. C. Webb, G. S. Figiel, and C. E. Spritzer. “Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study.Arch Gen Psychiatry 50, no. 1 (January 1993): 7–16. https://doi.org/10.1001/archpsyc.1993.01820130009002.
Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, et al. Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry. 1993 Jan;50(1):7–16.
Coffey, C. E., et al. “Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study.Arch Gen Psychiatry, vol. 50, no. 1, Jan. 1993, pp. 7–16. Pubmed, doi:10.1001/archpsyc.1993.01820130009002.
Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, Figiel GS, Spritzer CE. Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry. 1993 Jan;50(1):7–16.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

January 1993

Volume

50

Issue

1

Start / End Page

7 / 16

Location

United States

Related Subject Headings

  • Psychiatry
  • Odds Ratio
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hospitalization
  • Hippocampus
  • Functional Laterality
  • Female