Skip to main content

Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis.

Publication ,  Journal Article
Monach, PA; Kümpers, P; Lukasz, A; Tomasson, G; Specks, U; Stone, JH; Cuthbertson, D; Krischer, J; Carette, S; Ding, L; Hoffman, GS; Iklé, D ...
Published in: PLoS One
2012

The endothelial-specific Angiopoietin-Tie2 ligand-receptor system is an important regulator of endothelial activation. Binding of angiopoietin-2 (Ang-2) to Tie2 receptor renders the endothelial barrier responsive to pro-inflammatory cytokines. We previously showed that circulating Ang-2 correlated with disease severity in a small cohort of critically ill patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. The current study reassessed Ang-2 as a biomarker of disease activity and relapse in AAV. Circulating Ang-2 was measured in 162 patients with severe AAV (BVAS/WG≥3, with or without glomerulonephritis) in a clinical trial. Ang-2 levels during active AAV were compared to levels in the same patients during remission (BVAS/WG = 0). Levels in clinical subsets of AAV were compared, and association with future disease course was assessed. Ang-2 levels were elevated in severe disease (median 3.0 ng/ml, interquartile range 1.9-4.4) compared to healthy controls (1.2, 0.9-1.5). However, they did not reliably decline with successful treatment (median 2.6 ng/ml, interquartile range 1.9-3.8, median change -0.1). Ang-2 correlated weakly with BVAS/WG score (r = 0.17), moderately with markers of systemic inflammation (r = 0.25-0.41), and inversely with renal function (r = -0.36). Levels were higher in patients with glomerulonephritis, but levels adjusted for renal dysfunction were no different in patients with or without glomerulonephritis. Levels were higher in patients with newly diagnosed AAV and lower in patients in whom treatment had recently been started. Ang-2 levels during active disease did not predict response to treatment, and Ang-2 levels in remission did not predict time to flare. Thus, Ang-2 appears to have limited practical value in AAV as a biomarker of disease activity at time of measurement or for predicting future activity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

1

Start / End Page

e30197

Location

United States

Related Subject Headings

  • Remission Induction
  • Prognosis
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Kidney
  • Humans
  • Glomerular Filtration Rate
  • General Science & Technology
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Monach, P. A., Kümpers, P., Lukasz, A., Tomasson, G., Specks, U., Stone, J. H., … Merkel, P. A. (2012). Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. PLoS One, 7(1), e30197. https://doi.org/10.1371/journal.pone.0030197
Monach, Paul A., Philipp Kümpers, Alexander Lukasz, Gunnar Tomasson, Ulrich Specks, John H. Stone, David Cuthbertson, et al. “Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis.PLoS One 7, no. 1 (2012): e30197. https://doi.org/10.1371/journal.pone.0030197.
Monach PA, Kümpers P, Lukasz A, Tomasson G, Specks U, Stone JH, et al. Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. PLoS One. 2012;7(1):e30197.
Monach, Paul A., et al. “Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis.PLoS One, vol. 7, no. 1, 2012, p. e30197. Pubmed, doi:10.1371/journal.pone.0030197.
Monach PA, Kümpers P, Lukasz A, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Carette S, Ding L, Hoffman GS, Iklé D, Kallenberg CGM, Khalidi NA, Langford CA, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Haubitz M, Merkel PA. Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis. PLoS One. 2012;7(1):e30197.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2012

Volume

7

Issue

1

Start / End Page

e30197

Location

United States

Related Subject Headings

  • Remission Induction
  • Prognosis
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Kidney
  • Humans
  • Glomerular Filtration Rate
  • General Science & Technology
  • Female