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Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis.

Publication ,  Journal Article
Monach, PA; Tomasson, G; Specks, U; Stone, JH; Cuthbertson, D; Krischer, J; Ding, L; Fervenza, FC; Fessler, BJ; Hoffman, GS; Ikle, D; Seo, P ...
Published in: Arthritis Rheum
December 2011

OBJECTIVE: To identify biomarkers that distinguish between active antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and remission in a manner superior or complementary to established markers of systemic inflammation. METHODS: Markers of vascular injury and angiogenesis were measured before and after treatment in a large clinical trial in AAV: 163 subjects enrolled in the Rituximab in ANCA-Associated Vasculitis trial were screened for the present study. Serum levels of E-selectin, intercellular adhesion molecule 3 matrix metalloproteinase protein 1 (MMP-1), MMP-3, MMP-9, P-selectin, thrombomodulin, and vascular endothelial growth factor were measured at study screening (time of active disease) and at month 6. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels had been measured at the time of the clinical visit. The primary outcome measure was the difference in marker level between screening and month 6 among patients whose disease was in remission (Birmingham Vasculitis Activity Score for Wegener's granulomatosis [BVAS/WG] score of 0) at month 6. RESULTS: All patients had severe active vasculitis at screening (mean ± SD BVAS/WG score 8.6 ± 3.2). Among the 123 patients whose disease was clinically in remission at month 6, levels of all markers except E-selectin showed significant declines. MMP-3 levels were also higher among the 23 patients with active disease at month 6 than among the 123 patients whose disease was in remission. MMP-3 levels correlated weakly with ESR and CRP levels. CONCLUSION: Many markers of vascular injury and angiogenesis are elevated in severe active AAV and decline with treatment, but MMP-3 appears to distinguish active AAV from remission better than the other markers studied. Further study of MMP-3 is warranted to determine its clinical utility in combination with conventional markers of inflammation and ANCA titers.

Duke Scholars

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Published In

Arthritis Rheum

DOI

EISSN

1529-0131

Publication Date

December 2011

Volume

63

Issue

12

Start / End Page

3988 / 3997

Location

United States

Related Subject Headings

  • Vascular System Injuries
  • Rituximab
  • Remission Induction
  • Neovascularization, Pathologic
  • Middle Aged
  • Matrix Metalloproteinase 3
  • Male
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Monach, P. A., Tomasson, G., Specks, U., Stone, J. H., Cuthbertson, D., Krischer, J., … Merkel, P. A. (2011). Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum, 63(12), 3988–3997. https://doi.org/10.1002/art.30615
Monach, Paul A., Gunnar Tomasson, Ulrich Specks, John H. Stone, David Cuthbertson, Jeffrey Krischer, Linna Ding, et al. “Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis.Arthritis Rheum 63, no. 12 (December 2011): 3988–97. https://doi.org/10.1002/art.30615.
Monach PA, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, et al. Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2011 Dec;63(12):3988–97.
Monach, Paul A., et al. “Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis.Arthritis Rheum, vol. 63, no. 12, Dec. 2011, pp. 3988–97. Pubmed, doi:10.1002/art.30615.
Monach PA, Tomasson G, Specks U, Stone JH, Cuthbertson D, Krischer J, Ding L, Fervenza FC, Fessler BJ, Hoffman GS, Ikle D, Kallenberg CGM, Langford CA, Mueller M, Seo P, St Clair EW, Spiera R, Tchao N, Ytterberg SR, Gu Y-Z, Snyder RD, Merkel PA. Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 2011 Dec;63(12):3988–3997.
Journal cover image

Published In

Arthritis Rheum

DOI

EISSN

1529-0131

Publication Date

December 2011

Volume

63

Issue

12

Start / End Page

3988 / 3997

Location

United States

Related Subject Headings

  • Vascular System Injuries
  • Rituximab
  • Remission Induction
  • Neovascularization, Pathologic
  • Middle Aged
  • Matrix Metalloproteinase 3
  • Male
  • Humans
  • Follow-Up Studies
  • Female