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Measurement of fatigue in systemic lupus erythematosus: a systematic review.

Publication ,  Journal Article
Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue,
Published in: Arthritis Rheum
December 15, 2007

OBJECTIVE: To systematically review fatigue instruments used in patients with systemic lupus erythematosus (SLE) and to seek consensus on which instruments should be recommended for future studies and which data on comorbid conditions should be reported when evaluating fatigue in patients with SLE. METHODS: We used data from Medline and EMBase databases (from January 1970 to June 2006), clinical experts, and bibliographies. Data were extracted independently by 4 authors and reviewed by a working group and larger expert panel to produce a recommendation. Instruments were examined for construct validity, reliability, and responsiveness to change. Correlations between fatigue and some components of the Medical Outcomes Study Short Form 36 (SF-36), disease activity, and comorbidities were reviewed. RESULTS: We identified 34 studies that used 15 fatigue instruments in patients with SLE. The Fatigue Severity Scale (FSS) was used in 56% of the studies. The Systemic Lupus Activity Measure was significantly correlated with fatigue, but the Systemic Lupus Erythematosus Disease Activity Index was not. Fatigue was also correlated with pain, poor quality of sleep, depression, and with each subscale of the SF-36. CONCLUSION: The working group and expert panel recommend the 9-item FSS for evaluating fatigue in SLE patients. Responsiveness to change of fatigue instruments has not been well established in SLE and needs further study. The panel suggested that an important improvement or response could be a 15% decrease in the FSS. The effect of several important confounding factors of fatigue such as sleep disorders, depression, fibromyalgia, and anemia needs to be collected and reported.

Duke Scholars

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Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

December 15, 2007

Volume

57

Issue

8

Start / End Page

1348 / 1357

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Reproducibility of Results
  • Pain
  • Lupus Erythematosus, Systemic
  • Humans
  • Fatigue
  • Disability Evaluation
  • Depression
  • Arthritis & Rheumatology
  • 1117 Public Health and Health Services
 

Citation

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Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue, . (2007). Measurement of fatigue in systemic lupus erythematosus: a systematic review. Arthritis Rheum, 57(8), 1348–1357. https://doi.org/10.1002/art.23113
Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue, Peter A. “Measurement of fatigue in systemic lupus erythematosus: a systematic review.Arthritis Rheum 57, no. 8 (December 15, 2007): 1348–57. https://doi.org/10.1002/art.23113.
Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue. Measurement of fatigue in systemic lupus erythematosus: a systematic review. Arthritis Rheum. 2007 Dec 15;57(8):1348–57.
Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue, Peter A. “Measurement of fatigue in systemic lupus erythematosus: a systematic review.Arthritis Rheum, vol. 57, no. 8, Dec. 2007, pp. 1348–57. Pubmed, doi:10.1002/art.23113.
Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue. Measurement of fatigue in systemic lupus erythematosus: a systematic review. Arthritis Rheum. 2007 Dec 15;57(8):1348–1357.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

December 15, 2007

Volume

57

Issue

8

Start / End Page

1348 / 1357

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Reproducibility of Results
  • Pain
  • Lupus Erythematosus, Systemic
  • Humans
  • Fatigue
  • Disability Evaluation
  • Depression
  • Arthritis & Rheumatology
  • 1117 Public Health and Health Services