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Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures.

Publication ,  Journal Article
Manton, KG; Stallard, E; Creason, JP; Riggan, WB; Woodbury, MA
Published in: Computers and biomedical research, an international journal
April 1986

Compartment model approaches have been proposed for the analysis of the age incidence of specific types of cancer. These models represented the age increases in incidence as the result of a compound hazard function where individual level risks were described by the Weibull hazard function and where the population level hazard rate is a continuous mixture of the Weibull hazards. These formulations assumed that the mixing function, which described differences in risk due to different exposure histories, was constant after the age at which the model was first applied. In this paper we show how the mixing distribution can be allowed to change with time reflecting changing exposures. The model is fitted to U.S. lung cancer mortality data where for recent male cohorts there appear to be changing patterns of exposure possibly related to recent declines in male smoking. The implications for future lung cancer mortality trends in the United States are discussed.

Duke Scholars

Published In

Computers and biomedical research, an international journal

DOI

EISSN

1090-2368

ISSN

0010-4809

Publication Date

April 1986

Volume

19

Issue

2

Start / End Page

151 / 169

Related Subject Headings

  • United States
  • Risk
  • Neoplasms
  • Models, Biological
  • Middle Aged
  • Medical Informatics
  • Male
  • Lung Neoplasms
  • Humans
  • Epidemiologic Methods
 

Citation

APA
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ICMJE
MLA
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Manton, K. G., Stallard, E., Creason, J. P., Riggan, W. B., & Woodbury, M. A. (1986). Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures. Computers and Biomedical Research, an International Journal, 19(2), 151–169. https://doi.org/10.1016/0010-4809(86)90013-3
Manton, K. G., E. Stallard, J. P. Creason, W. B. Riggan, and M. A. Woodbury. “Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures.Computers and Biomedical Research, an International Journal 19, no. 2 (April 1986): 151–69. https://doi.org/10.1016/0010-4809(86)90013-3.
Manton KG, Stallard E, Creason JP, Riggan WB, Woodbury MA. Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures. Computers and biomedical research, an international journal. 1986 Apr;19(2):151–69.
Manton, K. G., et al. “Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures.Computers and Biomedical Research, an International Journal, vol. 19, no. 2, Apr. 1986, pp. 151–69. Epmc, doi:10.1016/0010-4809(86)90013-3.
Manton KG, Stallard E, Creason JP, Riggan WB, Woodbury MA. Compartment model approaches for estimating the parameters of a chronic disease process under changing risk factor exposures. Computers and biomedical research, an international journal. 1986 Apr;19(2):151–169.

Published In

Computers and biomedical research, an international journal

DOI

EISSN

1090-2368

ISSN

0010-4809

Publication Date

April 1986

Volume

19

Issue

2

Start / End Page

151 / 169

Related Subject Headings

  • United States
  • Risk
  • Neoplasms
  • Models, Biological
  • Middle Aged
  • Medical Informatics
  • Male
  • Lung Neoplasms
  • Humans
  • Epidemiologic Methods