Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.
Publication
, Journal Article
Steffens, DC; Taylor, WD; McQuoid, DR; Krishnan, KRR
Published in: Int J Geriatr Psychiatry
March 2008
OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject. RESULTS: In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension. CONCLUSIONS: The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.
Duke Scholars
Published In
Int J Geriatr Psychiatry
DOI
ISSN
0885-6230
Publication Date
March 2008
Volume
23
Issue
3
Start / End Page
244 / 248
Location
England
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Middle Aged
- Male
- Magnetic Resonance Imaging
- Humans
- Heterozygote
- Geriatrics
- Genotype
- Genetic Predisposition to Disease
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Steffens, D. C., Taylor, W. D., McQuoid, D. R., & Krishnan, K. R. R. (2008). Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression. Int J Geriatr Psychiatry, 23(3), 244–248. https://doi.org/10.1002/gps.1869
Steffens, David C., Warren D. Taylor, Douglas R. McQuoid, and K Ranga R. Krishnan. “Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.” Int J Geriatr Psychiatry 23, no. 3 (March 2008): 244–48. https://doi.org/10.1002/gps.1869.
Steffens DC, Taylor WD, McQuoid DR, Krishnan KRR. Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression. Int J Geriatr Psychiatry. 2008 Mar;23(3):244–8.
Steffens, David C., et al. “Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.” Int J Geriatr Psychiatry, vol. 23, no. 3, Mar. 2008, pp. 244–48. Pubmed, doi:10.1002/gps.1869.
Steffens DC, Taylor WD, McQuoid DR, Krishnan KRR. Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression. Int J Geriatr Psychiatry. 2008 Mar;23(3):244–248.
Published In
Int J Geriatr Psychiatry
DOI
ISSN
0885-6230
Publication Date
March 2008
Volume
23
Issue
3
Start / End Page
244 / 248
Location
England
Related Subject Headings
- Serotonin Plasma Membrane Transport Proteins
- Middle Aged
- Male
- Magnetic Resonance Imaging
- Humans
- Heterozygote
- Geriatrics
- Genotype
- Genetic Predisposition to Disease
- Female