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Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels.

Publication ,  Journal Article
Shou, M; Thirumurti, V; Rajanayagam, S; Lazarous, DF; Hodge, E; Stiber, JA; Pettiford, M; Elliott, E; Shah, SM; Unger, EF
Published in: J Am Coll Cardiol
April 1997

OBJECTIVES: We sought to evaluate the potential of basic fibroblast growth factor (bFGF) to enhance coronary collateral perfusion in dogs with chronic single-vessel coronary occlusion. A secondary goal was to examine whether the salutary effects of bFGF treatment, previously proved effective in the short term, would be maintained in the long term (6 months). BACKGROUND: bFGF, an angiogenic growth factor, is currently the subject of a Phase I trial in patients with ischemic heart disease. It has been shown to promote collateral development in dogs with progressive coronary occlusion when given during the period of natural collateralization. The effect of bFGF on quiescent collateral vessels, a subject of significant clinical importance, is uncertain. METHODS: Dogs were subjected to ameroid-induced occlusion of the left circumflex coronary artery and randomized to bFGF (1.74 mg/day for 7 days), a regimen previously proved effective, or to saline solution. Maximal collateral perfusion was assessed 6 months later, and the dogs were reassigned to a course of bFGF or saline solution. Collateral perfusion was reevaluated after the second treatment course. RESULTS: At 6 months, collateral function was identical in the groups treated initially with bFGF and saline solution. The subsequent course of bFGF did not induce further collateralization. CONCLUSIONS: Although we previously demonstrated the salutary effects of this bFGF regimen in the short term (5 weeks), collateral flow in control dogs reached parity with that of bFGF-treated dogs after 6 months. bFGF did not induce further collateralization in dogs with mature collateral vessels, underscoring the priming role of ischemia for bFGF-induced collateral development.

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Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

April 1997

Volume

29

Issue

5

Start / End Page

1102 / 1106

Location

United States

Related Subject Headings

  • Time Factors
  • Neovascularization, Physiologic
  • Microspheres
  • Male
  • Hemodynamics
  • Fibroblast Growth Factor 2
  • Female
  • Dogs
  • Coronary Vessels
  • Collateral Circulation
 

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Shou, M., Thirumurti, V., Rajanayagam, S., Lazarous, D. F., Hodge, E., Stiber, J. A., … Unger, E. F. (1997). Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. J Am Coll Cardiol, 29(5), 1102–1106. https://doi.org/10.1016/s0735-1097(97)00014-4
Shou, M., V. Thirumurti, S. Rajanayagam, D. F. Lazarous, E. Hodge, J. A. Stiber, M. Pettiford, E. Elliott, S. M. Shah, and E. F. Unger. “Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels.J Am Coll Cardiol 29, no. 5 (April 1997): 1102–6. https://doi.org/10.1016/s0735-1097(97)00014-4.
Shou M, Thirumurti V, Rajanayagam S, Lazarous DF, Hodge E, Stiber JA, et al. Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. J Am Coll Cardiol. 1997 Apr;29(5):1102–6.
Shou, M., et al. “Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels.J Am Coll Cardiol, vol. 29, no. 5, Apr. 1997, pp. 1102–06. Pubmed, doi:10.1016/s0735-1097(97)00014-4.
Shou M, Thirumurti V, Rajanayagam S, Lazarous DF, Hodge E, Stiber JA, Pettiford M, Elliott E, Shah SM, Unger EF. Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. J Am Coll Cardiol. 1997 Apr;29(5):1102–1106.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

April 1997

Volume

29

Issue

5

Start / End Page

1102 / 1106

Location

United States

Related Subject Headings

  • Time Factors
  • Neovascularization, Physiologic
  • Microspheres
  • Male
  • Hemodynamics
  • Fibroblast Growth Factor 2
  • Female
  • Dogs
  • Coronary Vessels
  • Collateral Circulation