The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.
Publication
, Journal Article
Huang, L; Sullenger, B; Juliano, R
Published in: J Drug Target
September 2010
Effective therapeutic utilization of antisense and siRNA oligonucleotides represents a major challenge to drug delivery science. Although many strategies and technologies have been applied to oligonucleotide delivery, a key issue remains the role of molecular or carrier size. In this brief review, we address some of the size-related parameters that regulate the biodistribution of oligonucleotides. We also reprise several recent studies that have examined the inter-relationship of size and shape in influencing delivery.
Duke Scholars
Published In
J Drug Target
DOI
EISSN
1029-2330
Publication Date
September 2010
Volume
18
Issue
8
Start / End Page
567 / 574
Location
England
Related Subject Headings
- RNA, Small Interfering
- Pharmacology & Pharmacy
- Particle Size
- Oligonucleotides, Antisense
- Nanoparticles
- Liposomes
- Humans
- Glomerular Filtration Rate
- Endothelial Cells
- Drug Carriers
Citation
APA
Chicago
ICMJE
MLA
NLM
Huang, L., Sullenger, B., & Juliano, R. (2010). The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. J Drug Target, 18(8), 567–574. https://doi.org/10.3109/10611861003734019
Huang, Leaf, Bruce Sullenger, and Rudy Juliano. “The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.” J Drug Target 18, no. 8 (September 2010): 567–74. https://doi.org/10.3109/10611861003734019.
Huang L, Sullenger B, Juliano R. The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. J Drug Target. 2010 Sep;18(8):567–74.
Huang, Leaf, et al. “The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.” J Drug Target, vol. 18, no. 8, Sept. 2010, pp. 567–74. Pubmed, doi:10.3109/10611861003734019.
Huang L, Sullenger B, Juliano R. The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. J Drug Target. 2010 Sep;18(8):567–574.
Published In
J Drug Target
DOI
EISSN
1029-2330
Publication Date
September 2010
Volume
18
Issue
8
Start / End Page
567 / 574
Location
England
Related Subject Headings
- RNA, Small Interfering
- Pharmacology & Pharmacy
- Particle Size
- Oligonucleotides, Antisense
- Nanoparticles
- Liposomes
- Humans
- Glomerular Filtration Rate
- Endothelial Cells
- Drug Carriers