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Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus.

Publication ,  Journal Article
Swartzwelder, HS; Wilson, WA; Tayyeb, MI
Published in: Alcohol Clin Exp Res
December 1995

The goal of this study was to assess the effects of ethanol on the induction of long-term potentiation (LTP) in hippocampal slices from immature versus mature rats. Population excitatory postsynaptic potentials (pEPSPs) were recorded from stratum radiatum of area CA1 of hippocampal slices using electrical stimulation of the Schaffer collateral/commissural fiber pathway. The slices were prepared from rats aged 15 to 25 or from 70 to 100 days. Long-term potentiation (LTP) of the pEPSP slope was induced using a single, theta-burst stimulus train in the presence or absence of 60 mM ethanol. Under control conditions, the stimulus train induced LTP in slices from both immature and mature animals. However, the magnitude of LTP was greater in slices from immature rats. When ethanol was present during the stimulus train, the magnitude of LTP in slices from mature animals did not differ significantly from the magnitude of LTP in control slices. However, ethanol virtually blocked the induction of LTP in slices from immature animals. These results indicate that memory-related synaptic plasticity in the hippocampus is attenuated by ethanol to a greater degree in immature versus mature animals.

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Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

December 1995

Volume

19

Issue

6

Start / End Page

1480 / 1485

Location

England

Related Subject Headings

  • Synapses
  • Substance Abuse
  • Rats, Sprague-Dawley
  • Rats
  • Neuronal Plasticity
  • Nerve Fibers
  • Membrane Potentials
  • Male
  • Long-Term Potentiation
  • Hippocampus
 

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Swartzwelder, H. S., Wilson, W. A., & Tayyeb, M. I. (1995). Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res, 19(6), 1480–1485. https://doi.org/10.1111/j.1530-0277.1995.tb01011.x
Swartzwelder, H. S., W. A. Wilson, and M. I. Tayyeb. “Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus.Alcohol Clin Exp Res 19, no. 6 (December 1995): 1480–85. https://doi.org/10.1111/j.1530-0277.1995.tb01011.x.
Swartzwelder HS, Wilson WA, Tayyeb MI. Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res. 1995 Dec;19(6):1480–5.
Swartzwelder, H. S., et al. “Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus.Alcohol Clin Exp Res, vol. 19, no. 6, Dec. 1995, pp. 1480–85. Pubmed, doi:10.1111/j.1530-0277.1995.tb01011.x.
Swartzwelder HS, Wilson WA, Tayyeb MI. Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res. 1995 Dec;19(6):1480–1485.
Journal cover image

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

December 1995

Volume

19

Issue

6

Start / End Page

1480 / 1485

Location

England

Related Subject Headings

  • Synapses
  • Substance Abuse
  • Rats, Sprague-Dawley
  • Rats
  • Neuronal Plasticity
  • Nerve Fibers
  • Membrane Potentials
  • Male
  • Long-Term Potentiation
  • Hippocampus