Copper in microbial pathogenesis: meddling with the metal.
Publication
, Journal Article
Samanovic, MI; Ding, C; Thiele, DJ; Darwin, KH
Published in: Cell host & microbe
February 2012
Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals. Numerous studies have focused on the impact of iron availability during bacterial and fungal infections, and increasing evidence suggests that copper is also involved in microbial pathogenesis. Not only is copper an essential cofactor for specific microbial enzymes, but several recent studies also strongly suggest that copper is used to restrict pathogen growth in vivo. Here, we review evidence that animals use copper as an antimicrobial weapon and that, in turn, microbes have developed mechanisms to counteract the toxic effects of copper.
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Published In
Cell host & microbe
DOI
EISSN
1934-6069
ISSN
1931-3128
Publication Date
February 2012
Volume
11
Issue
2
Start / End Page
106 / 115
Related Subject Headings
- Virulence
- Models, Biological
- Immunology
- Humans
- Host-Pathogen Interactions
- Copper
- Coenzymes
- Bacteria
- Anti-Infective Agents
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Samanovic, M. I., Ding, C., Thiele, D. J., & Darwin, K. H. (2012). Copper in microbial pathogenesis: meddling with the metal. Cell Host & Microbe, 11(2), 106–115. https://doi.org/10.1016/j.chom.2012.01.009
Samanovic, Marie I., Chen Ding, Dennis J. Thiele, and K Heran Darwin. “Copper in microbial pathogenesis: meddling with the metal.” Cell Host & Microbe 11, no. 2 (February 2012): 106–15. https://doi.org/10.1016/j.chom.2012.01.009.
Samanovic MI, Ding C, Thiele DJ, Darwin KH. Copper in microbial pathogenesis: meddling with the metal. Cell host & microbe. 2012 Feb;11(2):106–15.
Samanovic, Marie I., et al. “Copper in microbial pathogenesis: meddling with the metal.” Cell Host & Microbe, vol. 11, no. 2, Feb. 2012, pp. 106–15. Epmc, doi:10.1016/j.chom.2012.01.009.
Samanovic MI, Ding C, Thiele DJ, Darwin KH. Copper in microbial pathogenesis: meddling with the metal. Cell host & microbe. 2012 Feb;11(2):106–115.
Published In
Cell host & microbe
DOI
EISSN
1934-6069
ISSN
1931-3128
Publication Date
February 2012
Volume
11
Issue
2
Start / End Page
106 / 115
Related Subject Headings
- Virulence
- Models, Biological
- Immunology
- Humans
- Host-Pathogen Interactions
- Copper
- Coenzymes
- Bacteria
- Anti-Infective Agents
- Animals