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Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.

Publication ,  Journal Article
Puig, S; Askeland, E; Thiele, DJ
Published in: Cell
January 2005

Iron (Fe) is an essential micronutrient for virtually all organisms and serves as a cofactor for a wide variety of vital cellular processes. Although Fe deficiency is the primary nutritional disorder in the world, cellular responses to Fe deprivation are poorly understood. We have discovered a posttranscriptional regulatory process controlled by Fe deficiency, which coordinately drives widespread metabolic reprogramming. We demonstrate that, in response to Fe deficiency, the Saccharomyces cerevisiae Cth2 protein specifically downregulates mRNAs encoding proteins that participate in many Fe-dependent processes. mRNA turnover requires the binding of Cth2, an RNA binding protein conserved in plants and mammals, to specific AU-rich elements in the 3' untranslated region of mRNAs targeted for degradation. These studies elucidate coordinated global metabolic reprogramming in response to Fe deficiency and identify a mechanism for achieving this by targeting specific mRNA molecules for degradation, thereby facilitating the utilization of limited cellular Fe levels.

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Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

January 2005

Volume

120

Issue

1

Start / End Page

99 / 110

Related Subject Headings

  • Tristetraprolin
  • Transcription, Genetic
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • RNA, Messenger
  • RNA Processing, Post-Transcriptional
  • Plasmids
  • Mutation
  • Molecular Sequence Data
  • Iron
 

Citation

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Puig, S., Askeland, E., & Thiele, D. J. (2005). Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell, 120(1), 99–110. https://doi.org/10.1016/j.cell.2004.11.032
Puig, Sergi, Eric Askeland, and Dennis J. Thiele. “Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.Cell 120, no. 1 (January 2005): 99–110. https://doi.org/10.1016/j.cell.2004.11.032.
Puig, Sergi, et al. “Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.Cell, vol. 120, no. 1, Jan. 2005, pp. 99–110. Epmc, doi:10.1016/j.cell.2004.11.032.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

January 2005

Volume

120

Issue

1

Start / End Page

99 / 110

Related Subject Headings

  • Tristetraprolin
  • Transcription, Genetic
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • RNA, Messenger
  • RNA Processing, Post-Transcriptional
  • Plasmids
  • Mutation
  • Molecular Sequence Data
  • Iron