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Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.

Publication ,  Journal Article
Mann, SD; Perez, KL; McCracken, EKE; Shah, JP; Wong, TZ; Tornai, MP
Published in: J Oncol
2012

A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies were consented and imaged as part of this IRB-approved breast imaging study. For each of the seven subjects, one randomly selected breast was imaged prone-pendant using the dedicated, compact breast SPECT-CT system underneath the shielded patient support. Iteratively reconstructed and attenuation and/or scatter corrected images were coregistered; CT images were segmented into glandular and fatty tissue by three different methods; the average concentration of Sestamibi was determined from the SPECT data using the CT-based segmentation and previously established quantification techniques. Very minor differences between the segmentation methods were observed, and the results indicate an average image-based in vivo Sestamibi concentration of 0.10 ± 0.16 μCi/mL with no preferential uptake by glandular or fatty tissues.

Duke Scholars

Published In

J Oncol

DOI

EISSN

1687-8469

Publication Date

2012

Volume

2012

Start / End Page

146943

Location

Egypt

Related Subject Headings

  • 5203 Clinical and health psychology
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1108 Medical Microbiology
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Mann, S. D., Perez, K. L., McCracken, E. K. E., Shah, J. P., Wong, T. Z., & Tornai, M. P. (2012). Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT. J Oncol, 2012, 146943. https://doi.org/10.1155/2012/146943
Mann, Steve D., Kristy L. Perez, Emily K. E. McCracken, Jainil P. Shah, Terence Z. Wong, and Martin P. Tornai. “Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.J Oncol 2012 (2012): 146943. https://doi.org/10.1155/2012/146943.
Mann, Steve D., et al. “Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.J Oncol, vol. 2012, 2012, p. 146943. Pubmed, doi:10.1155/2012/146943.

Published In

J Oncol

DOI

EISSN

1687-8469

Publication Date

2012

Volume

2012

Start / End Page

146943

Location

Egypt

Related Subject Headings

  • 5203 Clinical and health psychology
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
  • 1108 Medical Microbiology
  • 1103 Clinical Sciences