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MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.

Publication ,  Journal Article
Said, SM; Yeh, TL; Greenwood, RS; Whitt, JK; Tupler, LA; Krishnan, KR
Published in: Neuroreport
August 12, 1996
Published version (DOI) Link to item

Volumes of cerebral gray and white matter were measured in 22 children with neurofibromatosis type 1 (NF1) and in 20 controls. Judgment of Line Orientation (JLO) and the Developmental Test of Visual-Motor Integration (DTVMI) were administered to 16 of the NF1 patients. General linear models analysis of covariance revealed significantly larger brain volumes in NF1 children than in controls, particularly in white matter, and particularly in girls. JLO and DTVMI performance were positively related to right-hemisphere gray-matter volume. The results implicate a failure of growth control in NF1, leading to aberrant neurodevelopment. Our findings also suggest a basis for refined understanding of learning disabilities, which are a prominent feature of NF1.

Duke Scholars

Larry A. Tupler
Author Larry A. Tupler Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...
K. Ranga Rama Krishnan
Author K. Ranga Rama Krishnan Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...

Published In

Neuroreport

DOI

10.1097/00001756-199608120-00015

ISSN

0959-4965

Publication Date

August 12, 1996

Volume

7

Issue

12

Start / End Page

1941 / 1944

Location

England

Related Subject Headings

  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neurofibromatoses
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Female
  • Child, Preschool
  • Child
 

Citation

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Said, S. M., Yeh, T. L., Greenwood, R. S., Whitt, J. K., Tupler, L. A., & Krishnan, K. R. (1996). MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis. Neuroreport, 7(12), 1941–1944. https://doi.org/10.1097/00001756-199608120-00015
Said, S. M., T. L. Yeh, R. S. Greenwood, J. K. Whitt, L. A. Tupler, and K. R. Krishnan. “MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.” Neuroreport 7, no. 12 (August 12, 1996): 1941–44. https://doi.org/10.1097/00001756-199608120-00015.
Said SM, Yeh TL, Greenwood RS, Whitt JK, Tupler LA, Krishnan KR. MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis. Neuroreport. 1996 Aug 12;7(12):1941–4.
Said, S. M., et al. “MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.” Neuroreport, vol. 7, no. 12, Aug. 1996, pp. 1941–44. Pubmed, doi:10.1097/00001756-199608120-00015.
Said SM, Yeh TL, Greenwood RS, Whitt JK, Tupler LA, Krishnan KR. MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis. Neuroreport. 1996 Aug 12;7(12):1941–1944.

Published In

Neuroreport

DOI

10.1097/00001756-199608120-00015

ISSN

0959-4965

Publication Date

August 12, 1996

Volume

7

Issue

12

Start / End Page

1941 / 1944

Location

England

Related Subject Headings

  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neurofibromatoses
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Female
  • Child, Preschool
  • Child