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Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid.

Publication ,  Journal Article
Fagerlin, A; Zikmund-Fisher, BJ; Nair, V; Derry, HA; McClure, JB; Greene, S; Stark, A; Hensley Alford, S; Lantz, P; Hayes, DF; Wiese, C ...
Published in: Breast cancer research and treatment
February 2010

Tamoxifen reduces primary breast cancer incidence, yet causes serious side effects. To date, few women with increased breast cancer risk have elected to use tamoxifen for chemoprevention. The objective of the study was to determine women's knowledge of and attitudes toward tamoxifen following exposure to a tailored decision aid (DA). A total of 632 women with a 5-year risk of breast cancer > or = 1.66% (Mean = 2.56, range = 1.7-17.3) were recruited from two healthcare organizations. Participants viewed an online DA that informed them about their 5-year risk of breast cancer and presented individually tailored content depicting the risks/benefits of tamoxifen prophylaxis. Outcome measures included behavioral intentions (to seek additional information about tamoxifen, to talk to a physician about tamoxifen, and to take tamoxifen); knowledge; and perceived risks and benefits of tamoxifen. After viewing the DA, 29% of participants said they intended to seek more information or talk to their doctor about tamoxifen, and only 6% believed they would take tamoxifen. Knowledge was considerable, with 63% of women answering at least 5 of 6 knowledge questions correctly. Participants were concerned about the risks of tamoxifen, and many believed that the benefits of tamoxifen did not outweigh the risks. This study is the largest to date to test women's preferences for taking tamoxifen and one of the largest to have tested the impact of a tailored DA. After viewing the DA, women demonstrated good understanding of tamoxifen's risks and benefits, but most were not interested in taking tamoxifen for breast cancer chemoprevention.

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Published In

Breast cancer research and treatment

DOI

EISSN

1573-7217

ISSN

0167-6806

Publication Date

February 2010

Volume

119

Issue

3

Start / End Page

613 / 620

Related Subject Headings

  • Tamoxifen
  • Selective Estrogen Receptor Modulators
  • Patient Education as Topic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Health Knowledge, Attitudes, Practice
  • Female
  • Decision Support Techniques
  • Decision Making
 

Citation

APA
Chicago
ICMJE
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Fagerlin, A., Zikmund-Fisher, B. J., Nair, V., Derry, H. A., McClure, J. B., Greene, S., … Ubel, P. A. (2010). Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid. Breast Cancer Research and Treatment, 119(3), 613–620. https://doi.org/10.1007/s10549-009-0618-4
Fagerlin, Angela, Brian J. Zikmund-Fisher, Vijayan Nair, Holly A. Derry, Jennifer B. McClure, Sarah Greene, Azadeh Stark, et al. “Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid.Breast Cancer Research and Treatment 119, no. 3 (February 2010): 613–20. https://doi.org/10.1007/s10549-009-0618-4.
Fagerlin A, Zikmund-Fisher BJ, Nair V, Derry HA, McClure JB, Greene S, et al. Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid. Breast cancer research and treatment. 2010 Feb;119(3):613–20.
Fagerlin, Angela, et al. “Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid.Breast Cancer Research and Treatment, vol. 119, no. 3, Feb. 2010, pp. 613–20. Epmc, doi:10.1007/s10549-009-0618-4.
Fagerlin A, Zikmund-Fisher BJ, Nair V, Derry HA, McClure JB, Greene S, Stark A, Hensley Alford S, Lantz P, Hayes DF, Wiese C, Claud Zweig S, Pitsch R, Jankovic A, Ubel PA. Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid. Breast cancer research and treatment. 2010 Feb;119(3):613–620.
Journal cover image

Published In

Breast cancer research and treatment

DOI

EISSN

1573-7217

ISSN

0167-6806

Publication Date

February 2010

Volume

119

Issue

3

Start / End Page

613 / 620

Related Subject Headings

  • Tamoxifen
  • Selective Estrogen Receptor Modulators
  • Patient Education as Topic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Health Knowledge, Attitudes, Practice
  • Female
  • Decision Support Techniques
  • Decision Making