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[Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts].

Publication ,  Journal Article
Shvartsman, AL; Sarantseva, SV; Runova, OL; Talalaeva, EI; Vitek, MP
Published in: Biofizika
2010

Experimental evidence has been obtained that mutations in the presenilin 1 (PS1) gene in familial Alzheimer's disease can lead to the disturbance of cell adhesion in model cell cultures. It was shown that, in L fibroblasts of mice with stable expression of GFP-PS1 cDNA containing G209V or E319G mutations, cell-cell interactions and the accumulation of GFP-PS1 cDNA in intercellular contacts are disturbed. Similar results were obtained in transfected human epithelial Hep2 cells. It is assumed that mutations in familial Alzheimer's disease lead to the disturbance of the functions of presenelin 1 in cell adhesion.

Duke Scholars

Published In

Biofizika

ISSN

0006-3029

Publication Date

2010

Volume

55

Issue

5

Start / End Page

862 / 867

Location

Russia (Federation)

Related Subject Headings

  • Presenilin-1
  • Mutation
  • Mice
  • Humans
  • Fibroblasts
  • Epithelial Cells
  • Cell Line
  • Cell Adhesion
  • Biophysics
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shvartsman, A. L., Sarantseva, S. V., Runova, O. L., Talalaeva, E. I., & Vitek, M. P. (2010). [Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts]. Biofizika, 55(5), 862–867.
Shvartsman, A. L., S. V. Sarantseva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “[Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts].Biofizika 55, no. 5 (2010): 862–67.
Shvartsman AL, Sarantseva SV, Runova OL, Talalaeva EI, Vitek MP. [Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts]. Biofizika. 2010;55(5):862–7.
Shvartsman AL, Sarantseva SV, Runova OL, Talalaeva EI, Vitek MP. [Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts]. Biofizika. 2010;55(5):862–867.

Published In

Biofizika

ISSN

0006-3029

Publication Date

2010

Volume

55

Issue

5

Start / End Page

862 / 867

Location

Russia (Federation)

Related Subject Headings

  • Presenilin-1
  • Mutation
  • Mice
  • Humans
  • Fibroblasts
  • Epithelial Cells
  • Cell Line
  • Cell Adhesion
  • Biophysics
  • Animals