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Presenilin 1 expression on the cell surface in motile polarized cells

Publication ,  Journal Article
Schwartsman, AL; Sarantseva, SV; Tatishcheva, YA; Runova, OL; Talalaeva, EI; Vitek, MP
Published in: Biophysics
October 1, 2006

Most cases of early-onset familial Alzheimer's disease are caused by mutations in the presenilin 1 gene. Nonetheless, the function of presenilin 1 are not yet completely understood. It was shown that endogenous presenilin 1, as well as the adhesion protein CD44, is concentrated on the surface of lamellipodia of polarized T cells (Jurkat cells) after adhesion to a collagen matrix. This phenomenon was not observed for another surface protein of T cells, T cell receptor, which is not involved in cell adhesion processes. In cultures of primary mouse cortical neurons, presenilin 1 was concentrated on the surface of the growth cone and at neurite contact sites. The concentration of presenilin 1 on the surface of structures that determine cell motility and intercellular contacts suggests that presenilin 1 plays an important role in cell adhesion in motile polarized cells. © Nauka/Interperiodica 2006.

Duke Scholars

Published In

Biophysics

DOI

EISSN

1555-6654

ISSN

0006-3509

Publication Date

October 1, 2006

Volume

51

Issue

5

Start / End Page

740 / 743

Related Subject Headings

  • Biophysics
  • 5199 Other physical sciences
  • 5105 Medical and biological physics
  • 0299 Other Physical Sciences
 

Citation

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MLA
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Schwartsman, A. L., Sarantseva, S. V., Tatishcheva, Y. A., Runova, O. L., Talalaeva, E. I., & Vitek, M. P. (2006). Presenilin 1 expression on the cell surface in motile polarized cells. Biophysics, 51(5), 740–743. https://doi.org/10.1134/S0006350906050125
Schwartsman, A. L., S. V. Sarantseva, Y. A. Tatishcheva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “Presenilin 1 expression on the cell surface in motile polarized cells.” Biophysics 51, no. 5 (October 1, 2006): 740–43. https://doi.org/10.1134/S0006350906050125.
Schwartsman AL, Sarantseva SV, Tatishcheva YA, Runova OL, Talalaeva EI, Vitek MP. Presenilin 1 expression on the cell surface in motile polarized cells. Biophysics. 2006 Oct 1;51(5):740–3.
Schwartsman, A. L., et al. “Presenilin 1 expression on the cell surface in motile polarized cells.” Biophysics, vol. 51, no. 5, Oct. 2006, pp. 740–43. Scopus, doi:10.1134/S0006350906050125.
Schwartsman AL, Sarantseva SV, Tatishcheva YA, Runova OL, Talalaeva EI, Vitek MP. Presenilin 1 expression on the cell surface in motile polarized cells. Biophysics. 2006 Oct 1;51(5):740–743.
Journal cover image

Published In

Biophysics

DOI

EISSN

1555-6654

ISSN

0006-3509

Publication Date

October 1, 2006

Volume

51

Issue

5

Start / End Page

740 / 743

Related Subject Headings

  • Biophysics
  • 5199 Other physical sciences
  • 5105 Medical and biological physics
  • 0299 Other Physical Sciences