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Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.

Publication ,  Journal Article
Vitek, MP
Published in: Neurobiol Aging
1989

Amyloid peptide precursor (APP) gene expression increases in the brains of patients with Alzheimer's disease (AD). Regulation of expression at the transcriptional and posttranscriptional levels contributes significantly to these increases. Polypeptide hormones stimulate the promoter of the APP gene resulting in increased levels of heterogeneous nuclear RNAs (hnRNA). Through splicing, these hnRNAs are processed into 3 or more mature APP RNAs. The amounts of each of these similar but nonidentical APP RNAs may yield ratios of APP proteins which are required for neuronal survival, pathogenesis of neurons and/or produce phenocopies of learning and memory mutants of Drosophila.

Duke Scholars

Published In

Neurobiol Aging

DOI

ISSN

0197-4580

Publication Date

1989

Volume

10

Issue

5

Start / End Page

471 / 473

Location

United States

Related Subject Headings

  • Protein Precursors
  • Neurology & Neurosurgery
  • Mutation
  • Humans
  • Gene Expression Regulation
  • Drosophila
  • Animals
  • Amyloid beta-Protein Precursor
  • Amyloid
  • Alzheimer Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vitek, M. P. (1989). Increasing amyloid peptide precursor production and its impact on Alzheimer's disease. Neurobiol Aging, 10(5), 471–473. https://doi.org/10.1016/0197-4580(89)90102-4
Vitek, M. P. “Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.Neurobiol Aging 10, no. 5 (1989): 471–73. https://doi.org/10.1016/0197-4580(89)90102-4.
Vitek, M. P. “Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.Neurobiol Aging, vol. 10, no. 5, 1989, pp. 471–73. Pubmed, doi:10.1016/0197-4580(89)90102-4.
Journal cover image

Published In

Neurobiol Aging

DOI

ISSN

0197-4580

Publication Date

1989

Volume

10

Issue

5

Start / End Page

471 / 473

Location

United States

Related Subject Headings

  • Protein Precursors
  • Neurology & Neurosurgery
  • Mutation
  • Humans
  • Gene Expression Regulation
  • Drosophila
  • Animals
  • Amyloid beta-Protein Precursor
  • Amyloid
  • Alzheimer Disease