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TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance.

Publication ,  Journal Article
Yuan, H; Fales, AM; Vo-Dinh, T
Published in: Journal of the American Chemical Society
July 2012

Gold nanoparticles have great potential in plasmonic photothermal therapy (photothermolysis), but their intracellular delivery and photothermolysis efficiency have yet to be optimized. We show that TAT-peptide-functionalized gold nanostars (NS) enter cells significantly more than bare or PEGylated NS. The cellular uptake mechanism involves actin-driven lipid raft-mediated macropinocytosis, where particles primarily accumulate in macropinosomes but may also leak out into the cytoplasm. After 4-h incubation of TAT-NS on BT549 breast cancer cells, photothermolysis was accomplished using 850 nm pulsed laser under 0.2 W/cm(2) irradiation, below the maximal permissible exposure of skin. These results demonstrate the enhanced intracellular delivery and efficient photothermolysis of TAT-NS, promising agents in cancer therapy.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

July 2012

Volume

134

Issue

28

Start / End Page

11358 / 11361

Related Subject Headings

  • Phototherapy
  • Microscopy, Electron, Transmission
  • Metal Nanoparticles
  • Light
  • Hyperthermia, Induced
  • Humans
  • Gold
  • General Chemistry
  • Gene Products, tat
  • Female
 

Citation

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Yuan, H., Fales, A. M., & Vo-Dinh, T. (2012). TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. Journal of the American Chemical Society, 134(28), 11358–11361. https://doi.org/10.1021/ja304180y
Yuan, Hsiangkuo, Andrew M. Fales, and Tuan Vo-Dinh. “TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance.Journal of the American Chemical Society 134, no. 28 (July 2012): 11358–61. https://doi.org/10.1021/ja304180y.
Yuan H, Fales AM, Vo-Dinh T. TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. Journal of the American Chemical Society. 2012 Jul;134(28):11358–61.
Yuan, Hsiangkuo, et al. “TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance.Journal of the American Chemical Society, vol. 134, no. 28, July 2012, pp. 11358–61. Epmc, doi:10.1021/ja304180y.
Yuan H, Fales AM, Vo-Dinh T. TAT peptide-functionalized gold nanostars: enhanced intracellular delivery and efficient NIR photothermal therapy using ultralow irradiance. Journal of the American Chemical Society. 2012 Jul;134(28):11358–11361.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

July 2012

Volume

134

Issue

28

Start / End Page

11358 / 11361

Related Subject Headings

  • Phototherapy
  • Microscopy, Electron, Transmission
  • Metal Nanoparticles
  • Light
  • Hyperthermia, Induced
  • Humans
  • Gold
  • General Chemistry
  • Gene Products, tat
  • Female