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Plasmonic coupling interference: A new approach for cancer diagnostics using SERS detection

Publication ,  Journal Article
Wang, HN; Vo-Dinh, T
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
June 12, 2012

We have developed a novel label-free approach referred to as plasmonic coupling interference (PCI) nanoprobes for nucleic acid detection using surface-enhanced Raman scattering (SERS). To induce a strong plasmonic coupling effect and SERS signal, a nano-network of silver nanoparticles having the Raman label located between adjacent nanoparticles is assembled by Raman-labeled nucleic acid duplexes. The PCI method then utilizes specific nucleic acid sequences of interest as competitor elements of the Raman-labeled DNA probes to interfere the formation of the nucleic acid-crosslinked nano-networks in a competitive binding process, resulting in a reduced SERS signal. We illustrate the potential of the PCI technique for biomedical applications by detecting single-nucleotide polymorphism (SNP) and microRNA sequences involved in breast cancers. The results of this study could lead to the development of nucleic acid diagnostic tools for biomedical diagnostics and biosensing applications using SERS detection. © 2012 SPIE.

Duke Scholars

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

June 12, 2012

Volume

8214
 

Citation

APA
Chicago
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Wang, H. N., & Vo-Dinh, T. (2012). Plasmonic coupling interference: A new approach for cancer diagnostics using SERS detection. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8214. https://doi.org/10.1117/12.917630
Wang, H. N., and T. Vo-Dinh. “Plasmonic coupling interference: A new approach for cancer diagnostics using SERS detection.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8214 (June 12, 2012). https://doi.org/10.1117/12.917630.
Wang HN, Vo-Dinh T. Plasmonic coupling interference: A new approach for cancer diagnostics using SERS detection. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2012 Jun 12;8214.
Wang, H. N., and T. Vo-Dinh. “Plasmonic coupling interference: A new approach for cancer diagnostics using SERS detection.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8214, June 2012. Scopus, doi:10.1117/12.917630.
Wang HN, Vo-Dinh T. Plasmonic coupling interference: A new approach for cancer diagnostics using SERS detection. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2012 Jun 12;8214.

Published In

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

DOI

ISSN

1605-7422

Publication Date

June 12, 2012

Volume

8214